DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-11

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	143/575 - (24%)
Similarity:	253/575 - (44%)	Gaps:	118/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLVVALLPVLLE---GARILGVFPIPSHSHYYHALPYLKKLASL----GHEITSVSPFPLK---- 65
            :|..:.|..||:   .|:||...||...||    :.::.|||.:    |.|:|...||.|.
Worm     3 LLTFSCLCFLLKVNYAAKILIFNPIFGFSH----VKFVSKLADIIADHGQEVTLFQPFHLALKNL 63

  Fly    66 EPVANIHDIPV----PELFDNIEEIVGNLTNRKGTWNEF---EYINQYTL--GLVEKVLENDGVR 121
            :.:....:|.:    |:.:|::      |.....|:.:|   :.:|...|  .::.::|..:..:
Worm    64 DGIVKNKNIEIINYYPDHYDDL------LKLETQTFPDFWDSQLMNNPVLMAFMLPRILGGEFKK 122

  Fly   122 --------REILQP-ESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSP 177
                    :|||:. :..:||:.|.:.:.|..:| ::.:...|.|.|.|   ..::|     :..
Worm   123 TTIQLIKDKEILKKLKDKKFDVAISETFELTGMY-MSHFLGVPCIPILS---AVRLD-----IFN 178

  Fly   178 LAYLQSPSFNWFDLDTYGGRL---GHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADK------ 233
            .|:.||.:|.:  |...|.:|   ..|:|              |...|||.:|.|:|.:
Worm   179 EAFGQSSAFGY--LTQQGSKLAPDAGFLD--------------RLNDVYRDFFSKMAFRGMAQYQ 227

  Fly   234 -----RSLSEITRNFALILVNQHFTMAPPRPY----VP---NIIEVGGM--------HVDQQPKA 278
                 ::...:...:..::......|....||    ||   .|:.:||:        |||    |
Worm   228 NDVIEKAAGHVVPYWKDLVKEAPVYMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVD----A 288

  Fly   279 LPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRI-LWKFDADEL---SD 339
            ||::.|..::  .:...:..|.|:.:||..:.::.:..||..|.|||..| :||::.|:|   ..
Worm   289 LPEEYEIILK--EKETTVLISFGSVIRSYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKK 351

  Fly   340 VPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGI 404
            :|.||.:..|.||..:||...||||:|||||.||:|..:.|.|.|.:|.|.||..|.:.:...|.
Worm   352 LPKNVHLKKWVPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGG 416

  Fly   405 GLVLNYRDMT-SDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLR----HK 464
            .:..:..|:. ..:..:|:..|:|...:..|||...|...:||::|:...:....:.::    ..
Worm   417 AIAYDKFDLVDGKKLTETVRDLVTNPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPNLRS 481

  Fly   465 GAPHMRVAGRNLDFITYHSLDVLGTFLL---AVWAILSIVVLCAIKLLRAILKSK 516
            ..|.:...|.    |.::.|||: .||:   .:.|.:|..::|  ::|..||..|
Worm   482 QIPEINQVGP----IAHYYLDVI-VFLIFVSIITAYISFQIVC--RILSRILSKK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	127/524 (24%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	119/473 (25%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	79/304 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810