DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-53

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_503771.1	Gene:	ugt-53 / 178744	WormBaseID:	WBGene00020182	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	144/581 - (24%)
Similarity:	235/581 - (40%)	Gaps:	138/581 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRLIVLVVAL------LPVLLEGARILGVFPIPSHSHYYHALPYLK----KLASLGHEITSVSPF 62
            :||::.:..|      |.:|...| ::|    |||      :.||:    ||.:.||.:..|  |
Worm     1 MRLLIFLTVLINFSSCLNILFYYA-VIG----PSH------IAYLRNTIGKLLARGHNVDVV--F 52

  Fly    63 PLKEPVANIHDIPVPELFDNIEEIVGNLTNRKGTW------------------NEFEYINQYTLG 109
            .:...:||:      :||.::..|..|.......|                  .|||..::....
Worm    53 AVYNELANL------DLFPDVRRIYYNRHADPDYWKKNANHFSNMFEKSPTPLGEFEIFHESGYQ 111

  Fly   110 LVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFD------APIIGIASYGTDWKI 168
            |. |:..||....|.|  :|.::|:            |.::.:|      ....||.|.|
Worm   112 LC-KIAINDLKLIEFL--KSGKYDI------------GFSSDYDPCGNILMTAAGIPSIG----- 156

  Fly   169 DELVGNVSPLAYLQSPSFNWFDLDTYGGRLGHFVD---QSMAWINWHWRHEERHEAVYRKYFPKI 230
                      :.:.:|.|           |.|.|.   .::|.:.....:.|...::|.|.|..|
Worm   157 ----------SLIATPIF-----------LPHIVSAGLPTVASVYGTSLYPEHDSSLYDKIFNLI 200

  Fly   231 ------------ADKRSLSEITRNFA--------------LILVNQHFTMAPPRPYVPNIIEVGG 269
                        .|::..:.||:.|.              :|.||.|..:...||..|.|..:||
Worm   201 RLTYYHYAISPDMDRKYNNLITKRFGNNFPDVGTIERGIDIIFVNSHDFLEQQRPMSPKIKYIGG 265

  Fly   270 MHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQ-RILWKFD 333
            |.: ::.|.||.:.|. |....:...:.||.||.|.:..:....|:..:..|...|. ..|||:|
Worm   266 MAI-RKAKQLPDEFEK-ILSVPKSAYVLFSFGTQVPTAKMPLPIRRNFVGAFKKFPNVTFLWKYD 328

  Fly   334 ADEL-SDV---PSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFR 394
            :.|| :|:   ..|:....|.||.::|....|||||:|.||.|.:|....|||:|.:|.|.||..
Worm   329 SLELDADIFQGVENIHRLEWLPQTELLHDNRVKLFISHMGLNSYLETATAGVPVLSIPLFADQQN 393

  Fly   395 NMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHY 459
            |.::.:.:|:||:|:...:|:...:..:|:||....:...|:..:....::|....||.|.|..:
Worm   394 NAQNTRDRGMGLLLDRDKLTTKNIESALHELLENPKYLSNARSISKMILEKPDKANDTFIHWLEF 458

  Fly   460 VLRHKGAPH-MRVAGRNLDFITYHSLDVLGTFLLAVWAILSIV---VLCAIKLLRAILKSK 516
            ..|:.|... :::.|..|....|:    .|..||.|:.||.|:   ||..|.|....:||:
Worm   459 TARNPGLGRVLKLPGAELSPFYYY----CGDILLLVFCILFIILHTVLRTINLPSRKIKSE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	125/520 (24%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	115/475 (24%)
ugt-53	NP_503771.1	UDPGT	29..497	CDD:330975	129/528 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14449
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710