DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-22

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	144/552 - (26%)
Similarity:	239/552 - (43%)	Gaps:	76/552 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLPVLL---------EGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---FPLKEPVA 69
            |||:||         |..:||....:..|||..........|...||::|.:.|   |..:...|
Worm     7 LLPLLLLLGSFVGLTEPYKILMYTNLFGHSHIKMLGAVSDTLTDAGHDLTVLMPVIDFKQENKTA 71

  Fly    70 -----NIHDI-PVPELFDNIEEIVGNLTNRKGTWNE---FEYINQYTLGLV-----EKVLENDGV 120
                 ||..| |..::...||.:...:|....|.|.   |...:...:..:     .||||:
Worm    72 MKSTKNIIKIQPGQDISKTIETMEKFMTQLWTTDNSNPLFMVFHAPAMSAIFASQCRKVLED--- 133

  Fly   121 RREILQP-ESLQFDLIIVDLWRLDALYGLAAYFDA----PIIGIASYGTDWKIDELVGNVSPLAY 180
             :|:::. .:..|||.|.:.:...|.    |.|:|    ..:.:.|......:.:.:|  .|:|
Worm   134 -KELIERLRAENFDLAITEPFDTCAY----ALFEAIKIRAHVAVLSCSRLDHVSKAIG--QPIA- 190

  Fly   181 LQSPSFNWFDLDTYGGRLG---------HFV--DQSMAWINWHWRHEERHEAVYRKYFPKIADKR 234
               ||:......|:|.|:.         ||:  |...::|.      :....|.::..|.:   |
Worm   191 ---PSYVPGTQSTHGERMTIWQRFMNILHFLMGDFLFSYIG------DEDFKVAKEIIPGV---R 243

  Fly   235 SLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKA--LPQDLEDFIQGAGEHGVIY 297
            |..|:....:.|..|....|..|.|....||.:||:.|..|.|:  ||:.... |.|..:..::
Worm   244 SWREVLPEASFIFTNHIPLMDFPAPTFDKIIPIGGISVKTQKKSLELPEKWNK-ILGLRKKNIL- 306

  Fly   298 FSLGTNVRSRNLSKDRRKILIDTFASLPQ-RILWKF--DADELSDVPSNVLISPWFPQQDILAHP 359
            .|.|:|.||.::.:..::.::....|:|. ..:||:  :.|.|:|...||.:..|.||.::|..|
Worm   307 VSFGSNARSADMPEHFKQNVLKVAESMPDVTFIWKYENEKDTLADHLDNVYLGDWLPQNELLGDP 371

  Fly   360 NVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDM-TSDEFKDTIH 423
            .:.||:|||||.|..|....|.|.:.:|.|.||.||...:|..|...||:..|: .::..::||.
Worm   372 RLSLFVTHGGLASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDLGNAETIRNTIK 436

  Fly   424 QLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLG 488
            ::|..:.:.|.|:|.|:...:||.||.||.|....:..:....|.|...||:..:|.|:.||::.
Worm   437 KVLENEKYRVNAERLAEMLNNQPTNPKDTLIKHVEFAAKFGQLPSMDPYGRHQSYIEYYLLDIIS 501

  Fly   489 TFLLAVWAILSI---VVLCAIKLLRAILKSKK 517
            ..|:.:.....|   ::.|..::.....|.||
Worm   502 IALVLILTTSFISFQLIKCTFRMCCGSGKVKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	130/496 (26%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	116/452 (26%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	132/518 (25%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	80/260 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14115
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810