DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-24

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	135/578 - (23%)
Similarity:	236/578 - (40%)	Gaps:	109/578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPF------- 62
            |.::...|.:..||...|. .:||....:..|||..........|...||.:|...|.
Worm     1 MNLVTTFVFIFKLLNAALP-YKILIYSNLYGHSHIKVLNTVADTLTDAGHNVTIFRPIIESSQLD 64

  Fly    63 ----PLKEPVANIHDIPVPELFDNIEEIVGNL-----------------------TNRKGTWNEF 100
                ..|..:....|..|.|....|::..|:|                       |..|....:.
Worm    65 KSSVKTKNVIYIEPDEEVVEKMSKIDQFSGSLWTFDSTHPSAMIAKSNALVGFFGTQCKKVMRQQ 129

  Fly   101 EYINQ-----YTLGLVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIA 160
            :.::|     :.|.:.|.|   ||....|.:...::..:.::...|.|
Worm   130 KILDQLRDENFDLAITEPV---DGCAYAIFEYLKIRDHVTVLSCVRFD----------------- 174

  Fly   161 SYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRK 225
                  .:.:::|.....:|:......:.|..|...||.:|:                 :..|.:
Worm   175 ------HVSDILGQPIAPSYVPGTQSFFNDRMTMKERLLNFI-----------------QFYYGR 216

  Fly   226 Y-FPKIAD------------KRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPK 277
            : |..|.|            :||..|:....:.|..|....:..|.|....||.:||..|....|
Worm   217 FTFANILDQEYEMAKDILGIQRSWREVLPEASFIFSNHIPVLDFPSPTFDKIIPIGGFTVKTNEK 281

  Fly   278 ALPQDLE-DFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQ-RILWKFDADELSDV 340
            :|..|.: |.|....:..|: .|.|:|.:|:::.::.:|.|:..|:|:|. ..:||::...::..
Worm   282 SLKIDKKWDAILNIRKKNVL-ISFGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIWKYEDPNVNIA 345

  Fly   341 PS--NVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQG 403
            .:  ||.||.|.||.::||...|.:|:|||||.|.:|....|.|.:.:|.|.||.||.:.:|..|
Worm   346 KNLDNVFISSWLPQNELLADSRVTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHG 410

  Fly   404 IGLVLNYRDMTS-DEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAP 467
            ...||...|::: |..:||::.:||:.|:.:.||:.|:...:||.|..:..:....:..|....|
Worm   411 GAAVLQKTDLSNFDLVRDTLNDVLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHVEFAARFGKLP 475

  Fly   468 HMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRAILKSKKGNISPKQK 525
            .:...||:.:.:.|:.:|:| |.:|:|  ::|:..: .::|||.:|..   |.|.|.|
Worm   476 MLDNYGRHQNIVEYYFIDIL-TIILSV--LISVFYI-FVRLLRFMLSR---NRSTKDK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	115/514 (22%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	107/470 (23%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	123/534 (23%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	78/256 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810