DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-60

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001021158.1	Gene:	ugt-60 / 176366	WormBaseID:	WBGene00007402	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	123/544 - (22%)
Similarity:	219/544 - (40%)	Gaps:	105/544 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LPV------LLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEI------------TSVSPFPL 64
            ||:      :::..|||.:.|..::||........:.|..|||::            |..:..|
Worm     3 LPIFCIFLSVVDSLRILQIVPGFTNSHVLFNYRLAETLRFLGHDVKMWTQMEMAMLDTGNNKLP- 66

  Fly    65 KEPVANIHDIPVP----------ELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDG 119
             |.|:. :.||:.          ::|.::....|:..:...|..||:   ...:...|::|.:|.
Worm    67 -EGVSE-YRIPIHFTDTLKTEGLKVFQSMMFESGDAHDLWWTGQEFK---DMRVEACEQMLRHDE 126

  Fly   120 VRREILQPESLQFDLIIVDLWRLDAL---------------YGLAAY-FDAPIIGIASYGTDWKI 168
            ...|..:.:.  ||:.|.....|..|               :|.:.| |.|..:|:.:
Worm   127 SVYEDFRKDG--FDVAIAHFHDLCPLAIAKKMNVKRVIWITHGTSIYEFSAVQLGLRT------- 182

  Fly   169 DELVGNVSPLAYLQSPSFNWFDLDTYGGRLGH-------------FVDQSMAWINWHWRHEERHE 220
               :.:..|.. |.|..|:...||.....|.|             .||:::
Worm   183 ---IPSTIPHP-LSSAGFSQLFLDRVQNTLWHLSLLDFVNLPQNLLVDENL-------------- 229

  Fly   221 AVYRKYFPKIADKRSLSEITR-NFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQD-L 283
             .||::..  ||:..|.::.: ....:|:|....:..|||...:|...|.:.|.:..|.:.:. |
Worm   230 -FYREFVG--ADQDDLWDLAKTTVPSLLINGDRMLDFPRPLPIHIAFSGELGVSKGKKLVMEKWL 291

  Fly   284 EDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASL-PQRILWKFDADEL-SDVPSNVLI 346
            ||.|:...: |:|.|||||...:.|:........:..|..| ...|||:.:.... ::...|:.:
Worm   292 EDIIEKPSD-GLIVFSLGTVSNTTNMPAQMINSFLGAFGKLKTYTILWRMEKSVAGAEKYENLHL 355

  Fly   347 SPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYR 411
            ..|.||:||:.||.:||.|.|||..|.:|....|:|.:.:|.|.||..|.:..:..|:..||:..
Worm   356 VKWLPQKDIMRHPKMKLMIAHGGYNSFLEAAQAGIPAVLMPLFADQKINAKRAQRYGMATVLDKL 420

  Fly   412 DMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPH---MRVAG 473
            |:|.:.....|.:.| :..:...||:.:....||......:|:   .|.|:...:|.   ..:..
Worm   421 DLTINNVYGAIKEAL-KPEYSTNAKKLSAMLSDQVARKPYSAL---RYSLKLATSPKPSLFTLKS 481

  Fly   474 RNLDFITYHSLDVLGTFLLAVWAI 497
            ::|.|:.:|:||:....||..:.:
Worm   482 QHLSFLEFHNLDIFSIVLLTAFIV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	116/515 (23%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	108/468 (23%)
ugt-60	NP_001021158.1	Glycosyltransferase_GTB_type	17..>161	CDD:299143	30/151 (20%)
ugt-60	NP_001021158.1	egt	<253..464	CDD:223071	61/215 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840