Protein Alignment Ugt35E2 and UGT3A1

DIOPT Version :9

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_689617.3
• Gene: UGT3A1 / 133688
• HGNCID: 26625
• Length: 523
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 152/554 - (27%)
• Similarity: 261/554 - (47%)
• Gaps: 73/554 - (13%)

  Fly     5 MLVLRLIVLVVALLP--VLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP-----F 62
            |:..|:::||..||.  :|.|.|:||.:..: ..|||.......:.|...||.:|.:..     .
Human     1 MVGQRVLLLVAFLLSGVLLSEAAKILTISTL-GGSHYLLLDRVSQILQEHGHNVTMLHQSGKFLI 64

  Fly    63 P-LKEPVANI----------HDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLE 116
            | :||...:.          |...:.:.||:..|..  |..||    |.|       .|| |::|
Human    65 PDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIETA--LDGRK----ESE-------ALV-KLME 115

  Fly   117 NDGV-------RREILQPESLQ---FDLIIVDLWRLDALYGLAAYFDAPIIGI--ASYGTDWKID 169
            ..|.       |::|:  :||:   :||:.|:.:.. ..:.:|.....|.:.|  .::|:   :|
Human   116 IFGTQCSYLLSRKDIM--DSLKNENYDLVFVEAFDF-CSFLIAEKLVKPFVAILPTTFGS---LD 174

  Fly   170 ELVGNVSPLAYLQ-SPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADK 233
              .|..|||:|:. .||.....:| :.||:.:|: ...::....|..:...:...:::||: ..:
Human   175 --FGLPSPLSYVPVFPSLLTDHMD-FWGRVKNFL-MFFSFSRSQWDMQSTFDNTIKEHFPE-GSR 234

  Fly   234 RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYF 298
            ..||.:.....|..||..|.....||.:||.:.:||: :::..|.:||||::||...|:.|.:..
Human   235 PVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGL-MEKPIKPVPQDLDNFIANFGDAGFVLV 298

  Fly   299 SLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADEL-SDV--PSNVLISPWFPQQDILAHPN 360
            :.|:.:.:.. |::..|.:.:.||.|||.::|...:... .||  .:||.|..|.||.|:||||:
Human   299 AFGSMLNTHQ-SQEVLKKMHNAFAHLPQGVIWTCQSSHWPRDVHLATNVKIVDWLPQSDLLAHPS 362

  Fly   361 VKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQL 425
            ::||:||||..|.:|.|..||||:|||...||..||..:.|:..|:.:....:|:|....|:.|:
Human   363 IRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQV 427

  Fly   426 LTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDV---- 486
            :.:|.:.......:.....||::|....:.|..::|:..||.|::.......:...:.:||
Human   428 IEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDHILQTGGATHLKPYAFQQPWHEQYLIDVFVFL 492

  Fly   487 LGTFLLAVW---AILSIVVLCAIKLLRAILKSKK 517
            ||..|..:|   .:|.:|.    :.||...|.||
Human   493 LGLTLGTMWLCGKLLGVVA----RWLRGARKVKK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/489 (27%)
		YjiC	26..440	CDD:224732	122/445 (27%)
UGT3A1	NP_689617.3	UDPGT	23..523	CDD:330975	144/532 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740