Protein Alignment Ugt35E2 and UGT3A1

DIOPT Version :10

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: XP_047272663.1
• Gene: UGT3A1 / 133688
• HGNCID: 26625
• Length: 526
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 141/520 - (27%)
• Similarity: 242/520 - (46%)
• Gaps: 70/520 - (13%)

  Fly    37 SHYYHALPYLKKLASLGHEITSVSP-----FP-LKEPVANI----------HDIPVPELFDNIEE 85
            |||.......:.|...||.:|.:..     .| :||...:.          |...:.:.||:..|
Human    37 SHYLLLDRVSQILQEHGHNVTMLHQSGKFLIPDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIE 101

  Fly    86 IVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGV-------RREILQPESLQ---FDLIIVDLW 140
            ..  |..||    |.|       .|| |::|..|.       |::|:  :||:   :||:.|:.:
Human   102 TA--LDGRK----ESE-------ALV-KLMEIFGTQCSYLLSRKDIM--DSLKNENYDLVFVEAF 150

  Fly   141 RLDALYGLAAYFDAPIIGI--ASYGTDWKIDELVGNVSPLAYLQ-SPSFNWFDLDTYGGRLGHFV 202
            .. ..:.:|.....|.:.|  .::|:   :|  .|..|||:|:. .||.....:| :.||:.:|:
Human   151 DF-CSFLIAEKLVKPFVAILPTTFGS---LD--FGLPSPLSYVPVFPSLLTDHMD-FWGRVKNFL 208

  Fly   203 DQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEV 267
             ...::....|..:...:...:::||: ..:..||.:.....|..||..|.....||.:||.:.:
Human   209 -MFFSFSRSQWDMQSTFDNTIKEHFPE-GSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYI 271

  Fly   268 GGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKF 332
            ||: :::..|.:||||::||...|:.|.:..:.|:.:.:.. |::..|.:.:.||.|||.::|..
Human   272 GGL-MEKPIKPVPQDLDNFIANFGDAGFVLVAFGSMLNTHQ-SQEVLKKMHNAFAHLPQGVIWTC 334

  Fly   333 DADEL-SDV--PSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFR 394
            .:... .||  .:||.|..|.||.|:||||:::||:||||..|.:|.|..||||:|||...||..
Human   335 QSSHWPRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHG 399

  Fly   395 NMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHY 459
            ||..:.|:..|:.:....:|:|....|:.|::.:|.:.......:.....||::|....:.|..:
Human   400 NMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDH 464

  Fly   460 VLRHKGAPHMRVAGRNLDFITYHSLDV----LGTFLLAVW---AILSIVVLCAIKLLRAILKSKK 517
            :|:..||.|::.......:...:.:||    ||..|..:|   .:|.:|.    :.||...|.||
Human   465 ILQTGGATHLKPYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLGVVA----RWLRGARKVKK 525

  Fly   518  517
            Human   526  525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	MGT	31..443	CDD:273616	120/437 (27%)
		Glycosyltransferase_GTB-type	<247..517	CDD:471961	86/279 (31%)
UGT3A1	XP_047272663.1	Glycosyltransferase_GTB-type	36..526	CDD:471961	141/520 (27%)