DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	162/566 - (28%)
Similarity:	271/566 - (47%)	Gaps:	95/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLVVALLP-----VLLEGARILG--VFPIPSH-SHYYHALPYLKKLASLGHEITSVSPFPLKEPV 68
            :|..|.||     ::|.|: :||  :..:|.. ||:......::.|:..||:|.      :..|.
  Rat     4 LLPAARLPAGFLFLVLWGS-VLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIV------VLVPE 61

  Fly    69 ANI----------HDIPVPELFDNIEEI------VGNLTNRKGTWNEF-----------EYINQY 106
            .|:          ...|||.   |:||:      .||        |.|           ||.|
  Rat    62 VNLLLGESKYYRRKSFPVPY---NLEELRTRYRSFGN--------NHFAASSPLMAPLREYRN-- 113

  Fly   107 TLGLVE------KVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTD 165
            .:.:::      :.|..|......|:..  |||.:..|. .:.....||.|...|.:.:.. |..
  Rat   114 NMIVIDMCFFSCQSLLKDSATLSFLREN--QFDALFTDP-AMPCGVILAEYLKLPSVYLFR-GFP 174

  Fly   166 WKIDELVG-NVSPLAYLQSPSF--NWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYF 227
            ..::.::| :.||::|:  |.|  .:.|..|:..||.:|:...:....:|        .:|.||.
  Rat   175 CSLEHMLGQSPSPVSYV--PRFYTKFSDHMTFPQRLANFIANILENYLYH--------CLYSKYE 229

  Fly   228 PKIAD--KR--SLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQ 288
            ...:|  ||  ||..:.:| :|.|:...|....|||.:||:|.:||.:..::.. |.|:.|.::.
  Rat   230 ILASDLLKRDVSLPALHQN-SLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGN-LSQEFEAYVN 292

  Fly   289 GAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQ 353
            .:||||::.||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.
  Rat   293 ASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQN 355

  Fly   354 DILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEF 418
            |:|.||..:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.
  Rat   356 DLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDL 420

  Fly   419 KDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHS 483
            ::.:..::..||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..|||
  Rat   421 ENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHS 485

  Fly   484 LDVLGTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            |||:| ||||:  :|::|.:    ||....:..  ..||.:....|
  Rat   486 LDVIG-FLLAI--VLTVVFIVYKSCAYGCRKCF--GGKGRVKKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	139/500 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	119/456 (26%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	153/530 (29%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	153/536 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860