DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and UGT2B11

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001064.1	Gene:	UGT2B11 / 10720	HGNCID:	12545	Length:	529	Species:	Homo sapiens

Alignment Length:	516	Identity:	139/516 - (26%)
Similarity:	255/516 - (49%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 HSHYYHALPYLKKLASLGHEIT------SVSPFPLKEPVANIHDIPVPELFDNIEEIVGNLTNRK 94
            :||:.:....||:|...|||:|      |:...|...........|........|.|:.....|
Human    33 YSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKR- 96

  Fly    95 GTWNEFE------YINQ--------YTL--GLVEKVLENDGVRREILQPESLQFDLIIVDLWRLD 143
              |::..      |.:|        |.:  ...:.|:.|..|.:::   :..:||::..     |
Human    97 --WSDIRKDSFWLYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKL---QESRFDIVFA-----D 151

  Fly   144 ALYG----LAAYFDAPIIGIASYGTDWKIDELVGN-VSPLAYLQSPSFNWFDLDTYGGRLGHFVD 203
            |::.    |||..:...:....:...:.|:...|. :.|.:|:........|..|:..|:.:.:
Human   152 AVFPCGELLAALLNIRFVYSLRFTPGYTIERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMI- 215

  Fly   204 QSMAWINWHWRHEERHEAVYRKYFPKIADK-RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEV 267
             .:.:.::.::..:..:  :.:::.::..: .:|.|......:.|:...::...|.|::||:..|
Human   216 -YVLYFDFWFQMSDMKK--WDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFV 277

  Fly   268 GGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKF 332
            ||.|. :..|.||:::|:|:|.:||:||:.||||:.:  .|::.:|..::....|.:||::||:|
Human   278 GGFHC-KPAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRF 339

  Fly   333 DADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNME 397
            |.::...:..|..:..|.||.|:|.||..:.||||||.....|.|:.|:||:|:|.|:||..|:.
Human   340 DGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIA 404

  Fly   398 HIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLR 462
            |:||:|..:.|::..|:|.:..:.:..::.:..:.....:.:....|||:.|||.|::|..:|:.
Human   405 HMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMP 469

  Fly   463 HKGAPHMRVAGRNLDFITYHSLDVLGTFLLA-----VWAILSIVVLCAIKLLRAILKSKKG 518
            ||||.|:|||..:|.:..||||||:| ||||     ::.|....:.|..|..|   |.|||
Human   470 HKGAKHLRVAAHDLTWFQYHSLDVIG-FLLACVATVIFIITKFCLFCFWKFAR---KGKKG 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	120/472 (25%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	102/431 (24%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	136/513 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150476
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690