DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	584	Identity:	157/584 - (26%)
Similarity:	277/584 - (47%)	Gaps:	119/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPMSMLVLRLIVLVVALLPVLLE---------GARILGVFPIPSHSHYYHALPYLKKLASLGHEI 56
            ||:.|        ..|||.:||:         |.::| |:|: ..||:.:....|.:|...|||:
Mouse     1 MPVKM--------TAALLLLLLQLSGFFGSGTGGKVL-VWPM-EFSHWLNLKTILDELLKKGHEV 55

  Fly    57 TSVSP------------------FPLKEPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYI 103
            ..:.|                  :|....::.:.:|    .::::::.:..|. ::..|..|..:
Mouse    56 MVLRPSASLSYEVDNTSAIEFETYPTSYSLSELEEI----FWESLKKYIYELP-KQSFWGYFLML 115

  Fly   104 -------NQYTLGLVEKVLENDGVRREILQPESLQFDLIIVD-----------LWRLDALYGLAA 150
                   ::|...|.:.|:.|..:..::   :..:||:|:.|           :.::..:|.| .
Mouse   116 QEMVWVDSKYFESLCKDVVFNKELMTKL---QKSRFDVILADPFIPCGDLLAEVLKIPLVYSL-R 176

  Fly   151 YFD-----------------APIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRL 198
            :|.                 .|:: ::.........|.|.||   .|:....| ||  .|:..:
Mouse   177 FFPGSTYEKYSGGLPLPPSYVPVV-MSELSDRMTFMERVRNV---IYMLCFDF-WF--QTFNEK- 233

  Fly   199 GHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPN 263
                       ||:           :.|...:....:|||......:.|:..::.:..|.|.:||
Mouse   234 -----------NWN-----------QLYTEVLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPN 276

  Fly   264 IIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRI 328
            ...:||:|. :..|.||:::|||:|.:|||||:.||||:.|.|  ::::|..::....|.:||::
Mouse   277 FDFIGGLHC-RPAKPLPKEIEDFVQSSGEHGVVVFSLGSMVGS--ITEERANVIAAGLAQIPQKV 338

  Fly   329 LWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQF 393
            ||:|:..:...:.||..:..|.||.|:|.|...:.||||||.....|.|:.|:|::|:|.|.||:
Mouse   339 LWRFEGKKPETLGSNTRLYKWIPQNDLLGHSKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQY 403

  Fly   394 RNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTH 458
            .|:.|:||:|..:.|::..|:|.:....:..:..:.|:...|.|.:..:.|||:.|||.|::|..
Mouse   404 DNIVHLKAKGAAVRLDFLTMSSTDLHTALKTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIE 468

  Fly   459 YVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIV----VLCAIKLLRAILKSKKG 518
            :|:|||||.|:|||..:|.::.||||||||..|..|..::.|:    :.|..||.:|..| |||
Mouse   469 FVMRHKGAKHLRVAAHDLSWVQYHSLDVLGFLLACVLTVMFILKKCCLFCCQKLTKAGRK-KKG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	130/519 (25%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	110/466 (24%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	145/546 (27%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	94/240 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840400
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690