DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	522	Identity:	144/522 - (27%)
Similarity:	253/522 - (48%)	Gaps:	58/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VFPIPSHSHYYHALPYLKKLASLGHEITSVSPF------PLKEPVANIHDIPVPELFDNIEEIVG 88
            |:|: ..||:.:....|.:|...|||:|.:.|.      |.|.|.......|.....||:|....
Mouse    28 VWPM-EFSHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNLENFFI 91

  Fly    89 NLTNRKGTW-----------------NEFEYINQYTLGLVEKVLENDGVRREILQPESLQFDLII 136
            ...:   .|                 |..:..:.|.|.|.:.|:.|..:..::   :..:||:::
Mouse    92 KFVD---VWTYEMPRDTCLSYSPLLQNMIDEFSDYFLSLCKDVVSNKELMTKL---QESKFDVLL 150

  Fly   137 VDLWRLDALYG--LAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLG 199
            .|   ..|..|  :|.....|.:....:...::|::..|.     :|..||:....|...||::
Mouse   151 SD---PVASCGELIAELLQIPFLYSIRFSPGYQIEKSSGR-----FLLPPSYVPVILSGLGGQM- 206

  Fly   200 HFVD--QSMA-------WINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMA 255
            .|::  ::|.       |....  ::::.::.|.:|   :....:|:|......:.|:..::.:.
Mouse   207 TFIERVKNMICRLYFDFWFQMF--NDKKWDSFYSEY---LGRPTTLAETMGKAEMWLIRSNWDLE 266

  Fly   256 PPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDT 320
            .|.|.:||:..|||:|. :..|.||:|:|:|:|.:|:|||:.||||:.|  .|:::::...:...
Mouse   267 FPHPTLPNVDYVGGLHC-KPAKPLPKDMEEFVQSSGDHGVVVFSLGSMV--SNMTEEKANTIAWA 328

  Fly   321 FASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLG 385
            .|.:||::|||||....:.:..|..:..|.||.|:|.||..|.|:||||.....|.|:.|:||:|
Mouse   329 LAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEVIYHGIPMIG 393

  Fly   386 LPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPL 450
            :|.|.:|..|:.|:.|:|..:.||.|.|:..:..:.:.:::....:...|...:..:.|||..||
Mouse   394 IPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPFYKKNAIWLSTIHHDQPTKPL 458

  Fly   451 DTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRAILKS 515
            |.|::|..:|:|||.|.|:|..|.||.:..||.|||:|..|..|...:.:.|.|.:.:.|..:|.
Mouse   459 DRAVFWVEFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVAVTIVLTVKCLLFIYRFFVKK 523

  Fly   516 KK 517
            :|
Mouse   524 EK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	131/484 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	113/443 (26%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	139/501 (28%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	144/522 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840404
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690