DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	531	Identity:	148/531 - (27%)
Similarity:	262/531 - (49%)	Gaps:	60/531 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEIT---SVSPFPLKEPVANIH 72
            :.|::..:||...| ::| |||:.. ||:.:....::.|::.||::|   :.|...:||...:..
Zfish    14 LTLLLPSVPVAQCG-KVL-VFPVDG-SHWVNMNILVEALSAKGHDVTVMRTASSCYIKEFSPHYT 75

  Fly    73 DI----------PVPELF-DNIEEIV------GNLTNRKGTWNEFEYINQYTLGLVEKVLENDGV 120
            .|          .|.|.| ..|..|:      |:|..:...|..|..|.:....::..::|:..:
Zfish    76 SINLKSKGGYNKEVLEQFASRIMHILRDGSTWGHLKLQADMWQSFLKIFEAEREMIVNMIEDQQL 140

  Fly   121 RREILQPESLQFDLIIVDLWRLDALYG---LAAYFDAPIIGIASYGTDWK-IDELVGNV--SPLA 179
            .:.:   :..::|||:.|    ..::|   |..|...|::    |...|. .:|...::  |||:
Zfish   141 MQSL---KDAKYDLILTD----PNMFGGVILGHYLKLPMV----YNVRWAGYNEAHFSIAPSPLS 194

  Fly   180 YLQSPSFNWFDLDTYGGRLGH-----FVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEI 239
            |:..||....|..::..|:.:     |::...|.:     ....::|:..::   |....|...:
Zfish   195 YVPMPSLELSDRMSFLQRVYNVVMYIFIEIGAALV-----ISPINDALAERF---IGPGTSFLSL 251

  Fly   240 TRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNV 304
            .:...|.|....|....|||.:||:|.:.|... :..|.||||||||:|.:|:||||..||||.:
Zfish   252 VQGADLWLHRVDFVFEYPRPTMPNVIYMAGFQC-KPSKPLPQDLEDFVQSSGDHGVIIMSLGTLI 315

  Fly   305 RSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGG 369
              ..|..|..:.:.:.||.|||:|:|::.....|.:.:|.||..|.||.|:|.||..:.|:.|||
Zfish   316 --DKLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGG 378

  Fly   370 LQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVK 434
            .....|.|:.|||::|....:||..|:..::.:|....:::..|..:.|..|:.::|.:.|:...
Zfish   379 TNGIQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYREN 443

  Fly   435 AKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILS 499
            .:|.:..::|.|:.|||.||:|..:|:|||||.|:|.....:.:.:|||:||:...:.||    |
Zfish   444 MQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLISAV----S 504

  Fly   500 IVVLCAIKLLR 510
            :::|....::|
Zfish   505 LIILSIYAVIR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	135/488 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	118/444 (27%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	143/511 (28%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	145/518 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584479
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790