DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt5d1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170967.1	Gene:	ugt5d1 / 100415794	ZFINID:	ZDB-GENE-091118-36	Length:	532	Species:	Danio rerio

Alignment Length:	540	Identity:	157/540 - (29%)
Similarity:	267/540 - (49%)	Gaps:	64/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---------F 62
            |:..:.|.::...:...|.:|| ::|:.. ||:.:....:::|.|.||.||.:.|         .
Zfish    10 VITGLFLALSAFTLSCSGGKIL-LYPVDG-SHWVNMKVLIEELHSRGHSITVIRPKSSWYITEKS 72

  Fly    63 PLKEPVA---NIHDIPVPELFDNIEE--IVGNLTNRKGTWNEFEYIN-QYTL------------G 109
            ||...:.   |::|      |:|..|  :...:...:|..:...::. ||.|            .
Zfish    73 PLYTSITIQDNVND------FENFFEDYLSKAMEIERGEGSGLAFLKLQYDLFSMLSTAHEIACK 131

  Fly   110 LVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYG---LAAYFDAPIIGIASYGTDWKIDEL 171
            :|..:|| |.:..:.||.|  |:||::.|    .|:.|   ||.|...|::    ....| |...
Zfish   132 MVSIILE-DKMLVKKLQDE--QYDLMLTD----PAIAGGVFLAHYLKLPLV----LNVRW-ITSG 184

  Fly   172 VGNV----SPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIAD 232
            .|:.    ||::|:..|.....|...:..|:.:.:.::..::...:.....::.:..||   :..
Zfish   185 EGHFAIAPSPMSYIPLPGSGHTDKMGFAQRVKNVLFKTFTFLQNRFVVGPHYDILIDKY---LDY 246

  Fly   233 KRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIY 297
            |..:..:.:...:.|:...|....|||.:|||:.:||... :..|.||.|||.|.|.:||||.|.
Zfish   247 KTDIVGLIQAADIWLMRADFVFEFPRPTMPNIVYMGGFRC-KPSKPLPADLEAFAQSSGEHGFII 310

  Fly   298 FSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVK 362
            .||||.|:|  |..|....:...||.|||:::|:...|..|:|.:|.||..|.||.|:|.|..:|
Zfish   311 MSLGTLVKS--LPADMANAIAAAFARLPQKVIWRHLGDRPSNVGNNTLIVDWMPQNDLLGHSKIK 373

  Fly   363 LFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLT 427
            .|:.|||.....|.|..|||:||:|.|:|||.|:..::.:|.|.:|...::.::.|:..:.:.|.
Zfish   374 AFVAHGGTNGVQEAIFHGVPVLGVPLFFDQFDNLIRVQGKGAGKILKLSELNAEAFEQALRESLN 438

  Fly   428 EKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLL 492
            :.|:....:..:..:|||||.||||||:|..:|:|||||.|:|.....:.:.:|||:||    .|
Zfish   439 DGSYKRNMQTLSTLHRDQPMRPLDTAIFWIEHVIRHKGATHLRSEFYKMPWYSYHSVDV----FL 499

  Fly   493 AVWAILSIVVLCAIKLLRAI 512
            .::.:.::.:|..|.::|.:
Zfish   500 VLFIVAAVCMLSTIAVIRYV 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	146/491 (30%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	125/447 (28%)
ugt5d1	NP_001170967.1	UDPGT	28..527	CDD:278624	154/522 (30%)
ugt5d1	NP_001170967.1	egt	<267..506	CDD:223071	97/245 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585147
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690