DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	545	Identity:	149/545 - (27%)
Similarity:	266/545 - (48%)	Gaps:	83/545 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHE---ITSVSPFPLKEPVANI 71
            |.:.|:.:...|.:|.:|| |.|:.. ||:.:....:|.|...||.   |.:.:.:.:||.....
Zfish    13 LWITVMIIFGSLCDGGKIL-VAPLEG-SHWVNMDILIKALHGQGHTVDVIRNTNSWFVKENSTYY 75

  Fly    72 HDIPVPELFDNIEEIVGNLTNR-------KGTW----------NEFEY-INQYTLGLVEKVLEND 118
            :.|.:|:.....||.|.::..:       ||:|          ::..| .::....|:..:.|::
Zfish    76 NSITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKAVYESHKLVCRLITNIFESE 140

  Fly   119 GVRREILQPESLQFDLIIVDL-W----------RLDALYGL------AAYFD---APIIGIASYG 163
            .:.:.:   :..::||::.|. |          :|..:|.:      ..:||   :|:..|...|
Zfish   141 DILKAL---QEKKYDLMLTDPGWGTGIILAHKLKLPMVYNVRWTTPGEGHFDIAPSPMSYIPLTG 202

  Fly   164 TDWKIDELVGNVSPLAYLQS--PSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKY 226
            :        ||...:::.|.  ..|.:..||....|.                :..:::|:..||
Zfish   203 S--------GNTDKMSFFQRVINVFYYLLLDFQCSRF----------------NVPQYQALCDKY 243

  Fly   227 FPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAG 291
            |....|   ..::.:...|.|:...|....|||.:||||..||... ...|.||.|||||:|.:|
Zfish   244 FDPPVD---FYKLLQGADLWLMRVDFVFEFPRPTMPNIIYTGGFQC-TPTKPLPHDLEDFMQSSG 304

  Fly   292 EHGVIYFSLGT--NVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQD 354
            :||||..|||:  :|....:|.:    :...||.|||:::|::...:.|.:.:|.|:..|.||:|
Zfish   305 DHGVIVMSLGSFISVLPDYVSSE----IAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKD 365

  Fly   355 ILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFK 419
            :|.||..||||.|||.....|.::.|||::|:|||:||:.|:..::|:|...:::..::..:...
Zfish   366 LLGHPKTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLH 430

  Fly   420 DTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSL 484
            ..|.:::.|.|:.:..::.:..:||:|:.|||:||:|..:|:|||||.|:|.....:.:.:|||:
Zfish   431 AAIQEVINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSV 495

  Fly   485 DVLGTFLLAVWAILSIVVLCAIKLL 509
            ||..| |:||..|....:...::.|
Zfish   496 DVSVT-LIAVVLIFIYSMFVTVRYL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	135/502 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	117/458 (26%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	145/530 (27%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	93/245 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585075
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690