DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	555	Identity:	144/555 - (25%)
Similarity:	258/555 - (46%)	Gaps:	78/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRLIVLVVALLPVLLEG--ARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP--------- 61
            :||:|..::||.|...|  ..||..:  ...||:.:....|..|...||.:|.:.|
Zfish     1 MRLVVCFLSLLTVFSAGQCGNILVWY--TEGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAK 63

  Fly    62 ---------FPLKEPVANIHDIPVPELFDNIEEI-VGNLTNRKGTWNEFEYINQYTLGLVEKVLE 116
                     |.:.:...::.|     .||.:... |..:.|......:.::.|   ||...:.:.
Zfish    64 ESDRFSYQHFSVSKSAQDMQD-----FFDELMRFSVFEMDNSSFLEIQMKFFN---LGSQHQDMS 120

  Fly   117 ---NDGVRREILQPESL------QFDLIIVDLWRLDALYG----LAAYFDAPIIGIASYGTDWKI 168
               .||:   :..||.:      :||:::     .|.:|.    :|...:.|::....:......
Zfish   121 LSYCDGI---LKSPELMDKLKKGKFDVVL-----SDPMYPCSDIVAEELNVPLVYTFRFSVAHAA 177

  Fly   169 DELVGNV-SPLAYLQSPSFNWFDLDTYGGR----LGHFVDQSMAWINWHWRHEERHEAVYRKYFP 228
            :.:.|.: :|.:|:........|..::..|    |.:....:::.:.|     .|.:..|.:||.
Zfish   178 ERMCGQIPAPPSYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIW-----RRFDNYYTEYFG 237

  Fly   229 KIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEH 293
            :   ..|..|:.....:.|:..::....|||:|||...:||:|. ...|.||:|:|:|:|.:|:.
Zfish   238 R---STSYCEMMGKADIWLIRTYWDFEFPRPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDD 298

  Fly   294 GVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAH 358
            |::.|:||:.:  ..:.|:....:....|.:||::||::..::...:..|..|..|.||.|:|.|
Zfish   299 GIVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWIPQNDLLGH 361

  Fly   359 PNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVL-NYRDMTSDEFKDTI 422
            |..:.||||||.....|.|:.||||:|:|.|.||..||.|:..:...:|: :.:.|...|..|.:
Zfish   362 PKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKL 426

  Fly   423 HQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVL 487
            :.::.:.|:...|.|.:..:.|:||.|||.:::|..:|:|:|||.|:||...||.:..||.|||.
Zfish   427 NTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVF 491

  Fly   488 GTFLLAVWAILSIVVLCAIK-----LLRAILKSKK 517
             .||..|   |::|:....|     ::|...:||:
Zfish   492 -AFLTTV---LTLVLYICFKMAKFFIMRCCFRSKR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	124/497 (25%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	106/451 (24%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	137/536 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860