DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	566	Identity:	153/566 - (27%)
Similarity:	264/566 - (46%)	Gaps:	92/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEIT----SVSPFPLKEPVAN 70
            |:.|::..:.|...| |:| |.| ..:||:::....::.|....|.:|    |.||
Zfish     7 LVCLLLCGVDVGWSG-RVL-VMP-GEYSHWHNMRAIIEALVDRNHSVTVLVGSSSP--------- 59

  Fly    71 IHDIPVPEL----FD------NIEEIVGNLTNRKGTWNEFEYI------NQY-TLGLVEKVLE-- 116
                .||..    ||      |||:     ......|::|.|:      .:| |:..:.:|:.
Zfish    60 ----TVPHTQKARFDYHVFKVNIEK-----EEADAVWSDFIYLWMNETATKYETVSNIFQVMSRF 115

  Fly   117 ---NDGVRREILQPESLQ------FDLIIVD-LWRLDALYGLAAYFDAPIIGIASYGTDWKIDEL 171
               .|.|.:.:.:.:.||      :|::..| :.....|  :|...:.|::........:..:.:
Zfish   116 MTLTDEVCKGMFKEDLLQMLRESHYDVLFSDPMMPCSDL--MAQTLNIPLVLSLRATFAYSFERM 178

  Fly   172 VGNV-SPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEE-----RHEAVYRKY---- 226
            .|.: :|.:|:.:.|..           .|..|: |:::.   |.|.     .|:..::.|
Zfish   179 CGQMPAPPSYVPAASLR-----------DHLTDR-MSFME---RVENMLLYFSHDVFFKLYMMFT 228

  Fly   227 ----FPKIADK-RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDF 286
                :.:|..| .::.|......:.|:..::....|||:.||...|||:|. :..|.|.:::|:|
Zfish   229 FDRIYTEIRGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSKEMEEF 292

  Fly   287 IQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFP 351
            :|.:|:|||:.||||:.:  :||:.:|...:......:||:::|::.......:..|..|..|.|
Zfish   293 VQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIP 355

  Fly   352 QQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSD 416
            |.|:|.||..|.||||||.....|.|:.||||:|||.|.||..|:.|:|.:|..:||:...:.|.
Zfish   356 QNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESK 420

  Fly   417 EFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITY 481
            :..|.:..:|...|:.....|.:..:.||||.|||.|::|..:|:|:|||.|:||....|.:..|
Zfish   421 DLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQY 485

  Fly   482 HSLDVLGTFLLAVWAILSI--VVLCAIKLLRAILKSKKGNISPKQK 525
            |.||| ..|||::.|:::.  |..|.....|.:.|::....:.|.|
Zfish   486 HCLDV-AAFLLSIAALITFLWVKACCFLFRRCVRKTRPERKTQKSK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	135/505 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	116/461 (25%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	147/539 (27%)
		REC	<129..>178	CDD:302758	7/50 (14%)
		egt	<254..485	CDD:223071	86/233 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55988
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930