DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt1b5

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170813.1	Gene:	ugt1b5 / 100384899	ZFINID:	ZDB-GENE-080227-14	Length:	528	Species:	Danio rerio

Alignment Length:	572	Identity:	160/572 - (27%)
Similarity:	268/572 - (46%)	Gaps:	105/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSMLVLRLIVLVVA-----------------LLPVLLEGARILGVFPIPS----HSH-YYHALPY 45
            |..::..|:|.||.                 ||.|.::|:...||..:..    ..| ....:|.
Zfish     1 MHGVIFNLVVGVVCSAAMNQKPSRNSSWTGKLLVVPMDGSHWTGVKAVAEEMGRRGHTVIVVIPE 65

  Fly    46 LK-KLASLGHEITSVSPFPLKEPVAN------IHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYI 103
            :. :|....|.||...|...|..|.|      ::.:..||. ..::.:..|:.|       |..:
Zfish    66 ISMRLGPGKHYITKKFPVKYKPDVLNQMIAKLVNTLSAPEQ-SLLKRVTSNIYN-------FGKV 122

  Fly   104 NQYTLGLVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKI 168
            ..|.:...|.:.:...: .|.|:.::  ||.::.|    .|:         |...|.:|
Zfish   123 VDYFISTTESLFQEQEL-IEFLRDQN--FDAVLTD----PAM---------PTGAILAY------ 165

  Fly   169 DELVGNVS-PLAYL------QSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEER-------- 218
                 |:| |..|:      :|.:....|..:|..||  |...|.     |....||
Zfish   166 -----NLSVPAVYMLRGLMCESKATACPDPPSYIPRL--FTQNSD-----HMNFGERLMNTLASL 218

  Fly   219 ------------HEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMH 271
                        .|.|..|:..:..   |::||....|:.|:...||:..|:|.:|||..:||::
Zfish   219 MEPLMCKLKFSAFEEVTSKFLHRDV---SMTEILSTGAVWLMRYDFTLEFPKPLMPNITNIGGIN 280

  Fly   272 VDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADE 336
            .:.. ..|.:::|:|:.|:||||::.||||:.|.|  :.|::..|....|:.:|||:||::..:.
Zfish   281 CEVN-NPLTKEVEEFVNGSGEHGIVVFSLGSLVSS--MPKEKADIFFKAFSMIPQRVLWRYTGEI 342

  Fly   337 LSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKA 401
            .::||.||.:..|.||.|:|.||..:.||||||.....|.|..||||:.||.|.||..|:..:..
Zfish   343 PNNVPENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVAT 407

  Fly   402 QGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGA 466
            :|:|::|:..|:|.:...|.::.::...|:..|.::.:..:.|:|:.|||.|::||.:|:|||||
Zfish   408 RGVGVILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGA 472

  Fly   467 PHMRVAGRNLDFITYHSLDVLGTFLLAVWAI-LSIVVLCAIKLLRAILKSKK 517
            .|:|.|...|:::.||||||:|..||.|..: |:::..|::...|...|::|
Zfish   473 DHLRPAAHELNWLQYHSLDVIGFMLLIVLIVTLAMLKCCSLCWRRCCRKTQK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	137/496 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	118/452 (26%)
ugt1b5	NP_001170813.1	UDPGT	30..524	CDD:278624	154/541 (28%)
ugt1b5	NP_001170813.1	egt	<268..507	CDD:223071	94/241 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930