DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	562	Identity:	159/562 - (28%)
Similarity:	270/562 - (48%)	Gaps:	94/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEIT------------ 53
            ||.:.|...:.:...|...|..:| ::|:.. ||:.:....:..|....|.:|
Mouse     1 MLKNILLCSLQISLLGMSLGGNVL-IWPMEG-SHWLNVKIIIDELLRKEHNVTVLVASGALFITP 63

  Fly    54 -SVSPFPSEEPVKNIYDIY-VPEVLNSFDELLKQMT--------TPKNTWEFF----DATNEFVY 104
             |:||       ...::|| ||......:.::|...        :|...|.|:    ....|| :
Mouse    64 SSISP-------SLTFEIYPVPFGKEKIESVIKDFVLTWLENRPSPSTIWTFYKEMAKVIEEF-H 120

  Fly   105 NITKDVFNNDGVRRE---ILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCG--IDWK- 163
            .:::.:.  |||.:.   :.:..|.:|::::.|                |:.   |||  :..|
Mouse   121 LVSRGIC--DGVLKNEKLMSKLQKEKFEVLLSD----------------PVF---PCGDIVALKL 164

  Fly   164 ---------------IDEMVGN-PSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYE 212
                           :::..|. |.|.||:.:..|.|.:..:|..||.:.:...:.        :
Mouse   165 GIPFIYSLRFSPASTVEKHCGKVPFPPSYVPAILSELTDQMSFTDRVRNFISYRMQ--------D 221

  Fly   213 QKHEALYKK---YFPK-IAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPK 273
            ...|.|:|:   |:.| :.....|.|......:.|:..::....||||:||...|||:|. :..|
Mouse   222 YMFETLWKQWDSYYTKALGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHC-KPAK 285

  Fly   274 ALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPS 338
            .|.:::|:|:|.|||||::.||||:.|  ||:.|::..::..|...:||:|||:::.:....:.|
Mouse   286 PLPKEMEEFVQTSGEHGIVVFSLGSMV--KNLTDEKANLIASALAQIPQKVLWRYKGKIPDTLGS 348

  Fly   339 NVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLS 403
            |..:..|:||.|||.|||.:.||||||.....|:|::|.||:|:|.|.||..|:.|:|..|..:.
Mouse   349 NTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVE 413

  Fly   404 LNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVA 468
            :|.:.|||.:|...:..::.|..::..|......:.|||:|||:.||:|..:|:|||||.|:|||
Mouse   414 VNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA 478

  Fly   469 GRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISK 510
            ...||:|.:|||||:|.:|..:...|:.:....:|...|:.|
Mouse   479 AHDLSWFQYHSLDVIGFLLACVASAILLVAKCCLFIFQKVGK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	136/506 (27%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	146/502 (29%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	152/536 (28%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	93/222 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840245
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	1	0.950	-	0	Normalized mean entropy	S5610
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.640