DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	159/562 - (28%)
Similarity:	273/562 - (48%)	Gaps:	88/562 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IILLFPGFLYGA----RILALFPVPSHSHYYHALPYLKNLASLGHEIT----SVSPFPSEEPVKN 66
            ::||...|.:.:    ::| ::|: .:||:.:....|:.|...|||:|    |.|.|...:...:
  Rat     9 LLLLQISFCFKSGNCGKVL-VWPM-EYSHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKETSD 71

  Fly    67 IYDIYVPEVLNSFDELLKQMTTPKNTWEF-----------------FDATNEFVYNITKDVFNND 114
            :..:..|...:|.| |....|...|.|.:                 .|..:::...:.|:..:|
  Rat    72 LKFVTFPTSFSSHD-LENFFTRFVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSN- 134

  Fly   115 GVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCG------------------ID 161
              ::.:.:..:::||::..|                   .:.|||                  ..
  Rat   135 --KQFMTKLQESKFDVVFSD-------------------AIGPCGELIAELLQIPFLYSLRFSPG 178

  Fly   162 WKIDEMVGNP-SPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFN-WHWRY-EQKHEALYKKYF 223
            :.|::.:|.. .|.||:....|.|....||..||.::  :.:.:|: |...: |:|.:..|.|
  Rat   179 YTIEKYIGGVLFPPSYVPMIFSGLAGQMTFIERVHNM--ICMLYFDFWFQTFREKKWDPFYSK-- 239

  Fly   224 PKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGE 288
             .:.....|:||.....:.|:..::.|..|.|..|||..:||:|. :..|.|.:|:|||:|.|||
  Rat   240 -TLGRPTTLAEIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHC-KPAKPLPKDIEDFVQSSGE 302

  Fly   289 HGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLA 353
            |||:.||||:.||  ||.:::..|:..|...:||:|||:|:.::...:..|..:.|||||.|||.
  Rat   303 HGVVVFSLGSMVR--NMTEEKANIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLG 365

  Fly   354 HPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATI 418
            |||.|.|:||||.....|:||:|.||:|:|.|.:|..|:.|:...|..:.:|:..|:..::...:
  Rat   366 HPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNAL 430

  Fly   419 LQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVL 483
            .:::....::..|......:.|||.|||:.||:|..:|:|||||.|:|..|..|.::.:|||||:
  Rat   431 EEVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVI 495

  Fly   484 GTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQK 525
            |.:|..:.:.::..|...:|..         |..|||::|.|
  Rat   496 GFLLTCVAVTVVLALKCFLFVY---------RFFVKKEKKTK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	137/496 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	144/492 (29%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	154/544 (28%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	89/221 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344066
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690