DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	542	Identity:	161/542 - (29%)
Similarity:	266/542 - (49%)	Gaps:	62/542 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSV-----------SPF 58
            |||.|:.:|...  |..::|.: ||.. ||:.:....:..|.|.||.||.|           ||.
Zfish     8 GLFLLLCVLSRS--YAGKLLVV-PVEG-SHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPL 68

  Fly    59 PSEEPVKNIYDIYVPEVLNSF-DELLKQMTTPKNTWEFFDATNEFVY----------NITKDVFN 112
            .:...|.|  .::..:.:..| ..|||.....|:.|......:|.::          |:|..:|.
Zfish    69 YTSITVDN--GVFDDDFMEKFLPHLLKIQRQGKSFWNEMALADEMIHFVTETHKQSCNMTAILFE 131

  Fly   113 NDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN------P 171
            |:.:...:   ..|.:|:::.|. .|.:...||.....|::    ..:.|.:   .|.      |
Zfish   132 NETLMNSL---KDAAYDVVLTDP-AYGSGVLLAHRLGLPLV----YNVRWTV---YGEAHFDIAP 185

  Fly   172 SPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYF-PKIAETKPLSEI 235
            ||:||:......|.:..||..||.:::...:..:.:...:...::.|.:||| |.:    ....:
Zfish   186 SPLSYVPVSGLQLTDKMTFSQRVMNMMTYIMIRYKYSKNFGSPYQELTQKYFGPNV----NFFSL 246

  Fly   236 SQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNV 300
            .||..|.|:...||...|||.:|||:.:||... :..|.|..|||:|:|.|||||||..||||..
Zfish   247 LQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQC-KPAKPLPGDLEEFVQSSGEHGVIMMSLGTVF 310

  Fly   301 RTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGG 365
              ..::.:....:..||..|||:|:|::......::.:|.|:..||||.|||.|||.|||:.|||
Zfish   311 --GQLLSELNDEIAAAFAQLPQKVIWRYTGPRPANLGNNTLIVNWLPQNDLLGHPKTKLFVAHGG 373

  Fly   366 MQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVT 430
            .....|:|::|.|::|||..:||..|:..::..|....:.:  .|.|  :|..|:.|.|.....:
Zfish   374 TNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEF--ATLD--RAVFLEALKEVLHNPS 434

  Fly   431 ARIAGAR----YRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVIL 491
            .|....|    :.|||||||:.|::|..:|:|:|||||:|....::|:..:.|:||:.|::|::|
Zfish   435 YRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSIDVILTLMLMVL 499

  Fly   492 L-VIIAILLIIVFSVCKISKNI 512
            : |::.:..:..|.:|...|.:
Zfish   500 VFVLLTVYTMKYFCLCLFRKKV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	143/487 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	145/483 (30%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	155/526 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584429
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690