DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	591	Identity:	164/591 - (27%)
Similarity:	267/591 - (45%)	Gaps:	127/591 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASGLFYLIILLFPGFLYG--ARILALFPVP-SHSHYYHALPYLKNLASLGHEIT----SVSPFP 59
            :.||.. |:.||..|...|  .|:|.:   | .:||:::..|.::.|....|.:|    |.||
Zfish     1 MTSGAL-LVCLLLCGVDVGWSGRVLVM---PGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSP-- 59

  Fly    60 SEEPVKNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKD-----------VFNN 113
                       .||.             |.|..:|:    :.|..|:.|:           :|.|
Zfish    60 -----------TVPH-------------TQKERFEY----HVFKVNMEKEEADAAMRDMIHLFTN 96

  Fly   114 D------------GVRREILRPGKAQF-DLIIVDIWK------YDAFYS---------LAAYFEA 150
            |            .|..:.:..|...| .|..|.:.|      ||..:|         :|.....
Zfish    97 DTAAKYEGEFVMWKVMSKFVEFGDVYFRGLFDVGLLKTLRDSNYDVLFSDPMMPFSDLMAQKLNI 161

  Fly   151 PIIGLAPCGIDWKIDEMVGN-PSPMSYLQSP--SSYLYNLDTFGGRVAHVVEVAISWFNWHWRYE 212
            |.:........:..:.:.|. |:|.||:.:.  :.:|.:..:|..||.:::
Zfish   162 PQVISMRATFAYAAERLCGQMPAPPSYVPAVALTDHLTDRMSFMERVENML-------------- 212

  Fly   213 QKHEALYKKY---FPKIAE-----------TKP--LSEISQDIALVLVNQHFTLGPPRPYVPNVI 261
                 ||..:   ||.:|.           .||  :.|....:.:.|:..::....|||:.||..
Zfish   213 -----LYIVHSIAFPLVATFTFDGYYSEILGKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFK 272

  Fly   262 EVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLW 326
            .|||:|. :..|.|:::||:|:|.||:|||:.||||:.:  ||:..:|...:..|.|.:||:|:|
Zfish   273 FVGGLHC-KPAKPLSKELEEFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVW 334

  Fly   327 KFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTN 391
            ::..:..:.:..|..:..|:||.|||.|||.|.||||||.....|:|::|.||:|||.|.||..|
Zfish   335 RYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDN 399

  Fly   392 VDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYV 456
            :.|||..|..:.|:.|.|.|.:|...:..::....::.:.......:.|||||||:.||:|..:|
Zfish   400 LLHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFV 464

  Fly   457 LRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNI--STRLVVK 519
            :|:|||.|:||...:||::.:|.|||...:|.:..|    |..:.|.:.|.:.:..  .||...|
Zfish   465 MRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITAL----ITFLWVKACCFLFRRCVRKTRPERK 525

  Fly   520 KQRKQK 525
            :|:.:|
Zfish   526 RQKNKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	140/519 (27%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	144/512 (28%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	152/556 (27%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	92/238 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585007
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.690