DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	545	Identity:	155/545 - (28%)
Similarity:	276/545 - (50%)	Gaps:	68/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSV----SPFPSE 61
            |::..|:..:|.:|.....|.:|| :.|:.. ||:.:....:|.|...||.:..:    |.|..|
Zfish    29 MVSVSLWTTVITIFGSLCDGGKIL-VAPLEG-SHWVNMDILIKALHGQGHTVDVIRNANSWFIKE 91

  Fly    62 EPVKNIYD-IYVP-------EVLNSFDELLKQMTTPKNTW--------EFFDA---TNEFVYNIT 107
            .  ...|| |.:|       |....|...:.:....|.:|        ..|||   |:|.|..:.
Zfish    92 N--STYYDTITIPNTKGWDEEFAADFVYKMIKYEKEKGSWLSIVRLYLNVFDAVKKTHEMVCQLI 154

  Fly   108 KDVFNNDGVRREILRP-GKAQFDLIIVD-IWKYDAFYSLAAYFEAPII-------------GLAP 157
            .::.:::    |||:. .:.|:||::.| :|.....  ||...:.|::             .:||
Zfish   155 TNILDSE----EILKMLNEKQYDLMLTDPVWGTGII--LAHKLKLPMVYNVRWTTTGEGHFDIAP 213

  Fly   158 CGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKY 222
            ..:.:......||...||:.|...:|.:.|         ::::.:|.||     .::::|:..||
Zfish   214 SPMSYIPITGSGNTDRMSFFQRLKNYFFYL---------LLDLQLSHFN-----VKQYQAICDKY 264

  Fly   223 FPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSG 287
            |.....   ..|:.|...|.|:...|....|||.:||:|.:||... ...|.|..|||||:|.||
Zfish   265 FTSRVN---FHELLQGADLWLMRVDFVFEFPRPTMPNIIYIGGFQC-PPAKPLPHDLEDFMQSSG 325

  Fly   288 EHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLL 352
            :||||..|||:.:  .|:.::....:..||..|||:|:|::..::...:.:|.|:..|:||:|||
Zfish   326 DHGVIVMSLGSLI--GNLPENVTAEIAAAFARLPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLL 388

  Fly   353 AHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKAT 417
            .|||.|:||:|||....:|::::|.|::|:|||:||:.|:..::..|....|:..|:..:.|.|.
Zfish   389 GHPKTKVFISHGGTNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTLHAA 453

  Fly   418 ILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDV 482
            |.:::.|..:.:........::|:|:|||::|::|..:|:|||||.|:|....|:.::::||:||
Zfish   454 IQEVINEPSYRLNMHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDV 518

  Fly   483 LGTVLLVILLVIIAILLIIVFSVCK 507
            :.|:..|:|::...|.:.:.:...|
Zfish   519 VVTLFAVVLILTYCIFVTVRYLCVK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	139/492 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	142/488 (29%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	150/525 (29%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	89/242 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585079
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690