DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and UGT2B15

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001067.2	Gene:	UGT2B15 / 7366	HGNCID:	12546	Length:	530	Species:	Homo sapiens

Alignment Length:	548	Identity:	163/548 - (29%)
Similarity:	280/548 - (51%)	Gaps:	58/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLIILLFPGFLYGA--RILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPS-------EEP 63
            :|:|.|...|..|:  ::| ::|. .:||:.:....|:.|...|||:|.::...|       ...
Human     9 FLLIQLSCYFSSGSCGKVL-VWPT-EYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSA 71

  Fly    64 VKNIYDIYVPEVLNSF--DELLKQMT-----TPKNT------------WEFFDATNEFVYNITKD 109
            :|  .::|...:..::  |.|||.:.     ..|||            ||::|.:|:    :.||
Human    72 IK--LEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNK----LCKD 130

  Fly   110 VFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN-PSP 173
            ...|   ::.:::..:::||:|:.|... .....||..|..|.:......:.:..::..|. ..|
Human   131 AVLN---KKLMMKLQESKFDVILADALN-PCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFP 191

  Fly   174 MSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYE-QKHEALYKKYFPKIAETKPLSEISQ 237
            .||:....|.|.:...|..|:.:::.:....| |...|: :|.:..|.:.   :.....|.|...
Human   192 PSYVPVVMSELSDQMIFMERIKNMIHMLYFDF-WFQIYDLKKWDQFYSEV---LGRPTTLFETMG 252

  Fly   238 DIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRT 302
            ...:.|:..::....|||::|||..|||:|. :..|.|.:::|:|:|.|||:|::.||||:.:
Human   253 KAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC-KPAKPLPKEMEEFVQSSGENGIVVFSLGSMI-- 314

  Fly   303 KNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQ 367
            .||.::...::..|...:||:|||:|:.::...:.||..:.|||||.|||.|||.|.||||||..
Human   315 SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTN 379

  Fly   368 STIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTAR 432
            ...|:|::|.||:|:|.|.||..|:.|:|..|..||::...|:|.:|...:..::.:..::....
Human   380 GIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVM 444

  Fly   433 IAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAI 497
            .....:.|||||||:.||:|..:|:|||||.|:|||...|::..:|||||:..:|..:..||..|
Human   445 KLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFII 509

  Fly   498 LLIIVFSVCKISKNISTRLVVKKQRKQK 525
            ....:|...|::         ||.:|:|
Human   510 TKFCLFCFRKLA---------KKGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	140/482 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	146/478 (31%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	156/517 (30%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	153/512 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150278
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690