DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and UGT2B10

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001066.1	Gene:	UGT2B10 / 7365	HGNCID:	12544	Length:	528	Species:	Homo sapiens

Alignment Length:	520	Identity:	156/520 - (30%)
Similarity:	266/520 - (51%)	Gaps:	39/520 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEIT------SVSPFPSEEPVKNI 67
            |:|.|...|..|:....|.....:|.:.:....||.|...|||:|      |:...|::.....:
Human     9 LLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSASILFDPNDSSTLKL 73

  Fly    68 YDIYVPEVLNS-FDELLKQMT-----TPKNT-W-------EFFDATNEFVYNITKDVFNNDGVRR 118
             ::|...:..: |:.::.|:.     ..|:| |       |...|.|:.:.|..|||.:|..:.:
Human    74 -EVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMK 137

  Fly   119 EILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN-PSPMSYLQSPSS 182
            ::   .:::||::..|.: ......||..|..|.:........:..:...|. ..|.||:....|
Human   138 KL---QESRFDIVFADAY-LPCGELLAELFNIPFVYSHSFSPGYSFERHSGGFIFPPSYVPVVMS 198

  Fly   183 YLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKI-AETKPLSEISQDIALVLVNQ 246
            .|.:..||..||.:::.|....| |...:..|.   :.:::.:: .....|||..:...:.|:..
Human   199 KLSDQMTFMERVKNMLYVLYFDF-WFQIFNMKK---WDQFYSEVLGRPTTLSETMRKADIWLMRN 259

  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKR 311
            .:....|.|::|||..|||:|. :..|.|.:::|:|:|.|||:||:.||||:.|  .||.::|..
Human   260 SWNFKFPHPFLPNVDFVGGLHC-KPAKPLPKEMEEFVQSSGENGVVVFSLGSMV--SNMTEERAN 321

  Fly   312 ILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376
            ::..|...:||:|||:|:..:...:..|..:.||:||.|||.|||.:.||||||.....|:|::|
Human   322 VIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHG 386

  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQ 441
            .||:|:|.|:||..|:.|:|..|..:.::::.|:|.:|...:..::.:..::...........||
Human   387 IPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYKENIMKLSRIQHDQ 451

  Fly   442 PMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC 506
            |:|||:.||:|..:|:|||||.|:|||...|::|.:|||||:|     .||..:|.:|.|:...|
Human   452 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIG-----FLLACVATVLFIITKCC 511

Fly 507 506
Human 512 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	135/473 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	143/472 (30%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	151/506 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150478
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690