DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and UGT2B7

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001065.2	Gene:	UGT2B7 / 7364	HGNCID:	12554	Length:	529	Species:	Homo sapiens

Alignment Length:	501	Identity:	157/501 - (31%)
Similarity:	259/501 - (51%)	Gaps:	47/501 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HSHYYHALPYLKNLASLGHEIT------SVSPFPSEEPVKNIYDIYVPEV----LNSF--DELLK 84
            :||:.:....|..|...|||:|      |:...|:......| :||...:    |.:|  .::.:
Human    33 YSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKI-EIYPTSLTKTELENFIMQQIKR 96

  Fly    85 QMTTPKNT-WEFFDATNEFVY---NIT----KDVFNNDGVRREILRPGKAQFDLIIVDIWKYDAF 141
            ....||:| |.:|....|.:.   :||    |||.:|....:::   .:::||:|..     ||.
Human    97 WSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKV---QESRFDVIFA-----DAI 153

  Fly   142 YS----LAAYFEAPIIGLAPCGIDWKIDEMVGN-PSPMSYLQSPSSYLYNLDTFGGRVAHVVEVA 201
            :.    ||..|..|.:........:..::..|. ..|.||:....|.|.:..||..||.:::.|.
Human   154 FPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVL 218

  Fly   202 ISWFNWHWRYEQKHEALYKKYFPKI-AETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGG 265
            ...| |...::.|.   :.:::.:: .....|||......:.|:...:....|.|.:|||..|||
Human   219 YFDF-WFEIFDMKK---WDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGG 279

  Fly   266 MHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFED 330
            :|. :..|.|.:::|||:|.|||:||:.||||:.|  .||.::|..::..|...:||:|||:|:.
Human   280 LHC-KPAKPLPKEMEDFVQSSGENGVVVFSLGSMV--SNMTEERANVIASALAQIPQKVLWRFDG 341

  Fly   331 EELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHI 395
            .:...:..|..:.||:||.|||.|||.:.||||||.....|:|::|.||:|:|.|.||..|:.|:
Human   342 NKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHM 406

  Fly   396 KKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHK 460
            |..|..:.::::.|:|.:|...:.:::.:..::...........|||:|||:.||:|..:|:|||
Human   407 KARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHK 471

  Fly   461 GAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC 506
            ||.|:|||...|::|.:|||||:|     .|||.:|.::.||...|
Human   472 GAKHLRVAAHDLTWFQYHSLDVIG-----FLLVCVATVIFIVTKCC 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	135/454 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	149/476 (31%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	157/501 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150429
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0	Normalized mean entropy	S5610
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.640