DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	170/555 - (30%)
Similarity:	270/555 - (48%)	Gaps:	93/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIILLFPGFLYGARILALFPV---------PSH-SHYYHALPYLKNLASLGHEIT----SVSPFP 59
            |.:|:||        |||..:         ||. ||:.:....|:.|....|.:|    |.:.|.
  Rat     6 LQLLIFP--------LALTEIVLSGNVVIWPSDGSHWLNIKILLEELVQRNHSVTVLAASETLFI 62

  Fly    60 SEEP--VKNIYDIYVPEVLNSFDELLKQM--------TTPKNTWEFFDATNEF---VYNITKDVF 111
            :..|  ..:..:|.|....:..||:::.|        .||...|.|:....:.   .|.|.|.:.
  Rat    63 NSSPDAFISFEEIPVSYTRSKIDEMIEHMIALWLDHRPTPLTMWAFYKELGKLFAAFYKINKQIC 127

  Fly   112 NNDGVRRE---ILRPGKAQFDLIIVD---------------IWKYDAFYSLAAYFEAPIIGLAPC 158
              |||.:.   :.|..|..||::|.|               .:.|...:|.|...|      ..|
  Rat   128 --DGVLKNATLMARLQKGGFDVLISDPVTMCGELVALKLGIPFVYTLRFSPAFTVE------RHC 184

  Fly   159 GIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAIS-------WFNWHWRYEQKHE 216
            |   ||      |:|:||:.:..|.|.:..|||.||.:.:..::.       |..|:
  Rat   185 G---KI------PTPVSYVPAALSELTDQMTFGERVKNTISYSLQDYIFKSYWGEWN-------- 232

  Fly   217 ALYKKYFPKI-AETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLE 280
                .|:.:: .....|.|......:.|:..::....||||:||...|||:|. :..|.|.:::|
  Rat   233 ----SYYSRVLGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHC-KPAKPLPKEME 292

  Fly   281 DFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKW 345
            :|:|.||||||:.||||:.|  ||:.:::..::..|...:||:|||:::.:....:.||..:..|
  Rat   293 EFVQTSGEHGVVVFSLGSMV--KNLTEEKANLIASALAQIPQKVLWRYKGKIPATLGSNTRLFDW 355

  Fly   346 LPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMT 410
            :||.|||.|||.:.||||||.....|:|::|.||:|:|.|.||..|:.|:|..|..:.:|.:.||
  Rat   356 IPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMT 420

  Fly   411 SDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFF 475
            |.:|.:.:..::.|..::..|......:.|||:|||:.||:|..:|:|||||.|:|||...||:|
  Rat   421 SADLLSAVRAVINEPFYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWF 485

  Fly   476 THHSLDVLGTVLLVILLVIIAILLIIVFSVCKISK 510
            .:|||||:|.:|..:...|:.::...:|...||.|
  Rat   486 QYHSLDVIGFLLACMASAILLVIKCCLFVFQKIGK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	148/504 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	154/493 (31%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	163/531 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860