DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt5g1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001107914.1	Gene:	ugt5g1 / 570913	ZFINID:	ZDB-GENE-080305-10	Length:	528	Species:	Danio rerio

Alignment Length:	543	Identity:	159/543 - (29%)
Similarity:	261/543 - (48%)	Gaps:	77/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YGARILALFPVPSHSHYYHALPYLKNLASLGHEIT--------------------SVSPFPSEEP 63
            :|..|| :|| ...||:.:....|:.|.:.||..|                    :|:|..:|:.
Zfish    22 HGGNIL-VFP-EDGSHWVNMQVILRKLHTHGHSFTVVRSSKSWYIHENSALYNTITVNPVETEDV 84

  Fly    64 VKNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREI-------- 120
            .::.:::.:..      .|..|..:|  ...||:...: :..:.| ||:| ||.|.:
Zfish    85 GQDYFNMLLDR------SLALQKMSP--LVRFFEQQKD-ITTVLK-VFHN-GVLRMVSAMLDDAE 138

  Fly   121 ----LRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDW---KIDEMVGNPSPMSYLQ 178
                ||  :|:|||::.|. .:.|...:|.:.:.|::    ..:.|   ....|...|||.||:.
Zfish   139 LVKSLR--EAKFDLLLTDP-AFPAGVLVANFLQLPMV----YNVRWLNAGDAHMQTAPSPPSYVP 196

  Fly   179 SPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVL 243
            ..:|.|::..:|..||.:.:....|.....:.....:..|.:::||..::   |..:.|...:.|
Zfish   197 MYNSLLHDQMSFLQRVENFLRYLCSLLQERYVIVPIYRELLERHFPPGSD---LLSMQQSADIWL 258

  Fly   244 VNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDD 308
            :...|....|||.:||:|.:||... :..:||..|||:|:|.||||||::.|||.      ||..
Zfish   259 MRMDFVFDFPRPTMPNIIYMGGFQC-KPAQALPVDLEEFMQSSGEHGVVFMSLGA------MVGA 316

  Fly   309 RKRILIE----AFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQST 369
            ..|.:.|    ||..:||:|:|::..|....:.:|.|:.:|.||.|||.|||.:.|::|||....
Zfish   317 LPRTITEAIASAFAKIPQKVMWRYHGERPSTLGNNTLLLEWFPQNDLLGHPKTRAFVSHGGTNGI 381

  Fly   370 IESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIA 434
            .|:|::|.|:|.||..:|||.||..::.......|....:||.|....:..:|....:..:.|..
Zfish   382 YEAIYHGVPVLALPLLFDQFDNVMRLQVRNAARVLQVATLTSQEFLEGLKDVLENPLYRSSIRKM 446

  Fly   435 GARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILL 499
            ...:||||:.||::|.:|..||:|||||.|:|.....|:::::|||||     ||.||.|..|..
Zfish   447 SELHRDQPISPLDSATFWIEYVMRHKGAAHLRSEANNLAWYSYHSLDV-----LVFLLAIAVIAF 506

  Fly   500 IIVFSVCKISKNISTRLVVKKQR 522
            .....||:.   :..|..:||::
Zfish   507 WTSVYVCRF---LCCRKSIKKRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	137/480 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	143/489 (29%)
ugt5g1	NP_001107914.1	UDPGT	24..526	CDD:278624	158/539 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584621
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790