DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	555	Identity:	167/555 - (30%)
Similarity:	287/555 - (51%)	Gaps:	72/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLY-GARILALFPVP-SHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNIY 68
            |:..||.|| |||. |.:||.   || ..||:.:....:|.|...||.|..:....|.. ||...
Zfish    13 LWITIIPLF-GFLCDGGKILV---VPLEGSHWLNMDILIKALHGKGHSIDVIRNTNSWY-VKEKS 72

  Fly    69 DIY----VPEVLNSFDELLKQMTTP-------KNTW-----EFFDAT------NEFVYNITKDVF 111
            |.|    :|:.....:|.:..|.:.       |::|     .|||:.      .:.|.:||..:|
Zfish    73 DYYNSITIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLFFDSVIDNYEMTKMVCDITTSIF 137

  Fly   112 NNDGVRREILRP-GKAQFDLIIVD-IWKYDAFYSLAAYFEAPIIGLAPCGIDW--KIDEMVGN-- 170
            .::    |||:. .:.|:||::.| :|.....  ||...:.|::    ..:.|  .:|   |:
Zfish   138 ESE----EILKTLQEKQYDLMLTDPVWGMGII--LAHKLKLPMV----YNVRWTTTVD---GHFN 189

  Fly   171 --PSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQ----KHEALYKKYFPKIAET 229
              ||||||:....|...:..:|..||.::    |.:|....:|.:    :::|:..|||....:.
Zfish   190 IAPSPMSYIPITGSGNTDRMSFFQRVKNI----IFYFTNDIKYSRFSLPQYQAICDKYFDPPVDF 250

  Fly   230 KPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYF 294
            ..|.: ..||.|:.|:  |....|||.:||:|..||... ...|.|..|||||:|.||:||||..
Zfish   251 YQLLQ-GADIWLMRVD--FVFEFPRPTMPNIIYTGGFQC-TPAKPLPHDLEDFMQSSGDHGVIVM 311

  Fly   295 SLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKL 359
            ||||.:..  :.:|....:..||..|||:|:|::..::...:.:|.|:..|:||:|||.|||.|:
Zfish   312 SLGTFISA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKV 374

  Fly   360 FITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTE 424
            |:.|||.....|::::|.|::|:|||:||:.|:..::..|....::..::..:.|.|.|.:::..
Zfish   375 FVAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINN 439

  Fly   425 KRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLV 489
            ..:.:|.:.....:.|:|:|||::|::|..:|:|||||.|:|....|:.::::||:||..|
Zfish   440 PSYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVAVT---- 500

  Fly   490 ILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQ 524
                :||::||.:||:..:.:.:..:...:|::.:
Zfish   501 ----LIAVVLIFIFSIFYVVRYVCIKCCSRKRKTE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	149/490 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	146/484 (30%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	158/536 (29%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	88/250 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585080
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690