DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt8

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	531	Identity:	148/531 - (27%)
Similarity:	259/531 - (48%)	Gaps:	52/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FYLIILLF---PGFLYGARILALFPVPSHSHYYHALPYLKNLASL----GHEITSVSPFPSEEPV 64
            |.|..||:   ....:.|:|:.:.|:...||.|    ..|.|||.    ||:...:.....|.|.
Zfish     5 FVLATLLWCLATSLSWAAKIVVVPPIMFESHLY----IFKTLASALHAEGHDTVFLVSEGREIPP 65

  Fly    65 KNIYDIY-VPEVLN--SFDELLKQMTTPKNTW-------EFFDATNEFVYNITKDVFNNDGVRRE 119
            .|.|.:. .|.:.|  |.|:.|:...  :|.:       |.||..:.:..|... |..:..|..:
Zfish    66 SNHYRLQRYPGIFNSTSADDFLQSKV--RNIFSGRLTALELFDILDHYSQNCDA-VVGSTSVMEQ 127

  Fly   120 ILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLA----PCGIDWKIDEMVGNPSPMSYLQSP 180
            :.|   ..|||::||.      ..:..:..|.|:|:.    ..|: |...| ||.|:|:||:...
Zfish   128 LKR---EHFDLLLVDP------NEMCGFVIAHILGVQYAVFSTGL-WYPAE-VGAPAPLSYVPEF 181

  Fly   181 SSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVN 245
            :|.|.:..:...|||:.....:|.|...:....|::.:.:||  .|..:..:.::.|:..|.::.
Zfish   182 NSLLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKY--NIQPSVSMHDLVQNSRLWMLC 244

  Fly   246 QHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRK 310
            ....|..|||.:|:|:.|||: :.:.|..|.|:.|.:::.:.|.|.:..|.|..|  |.:.||..
Zfish   245 TDMALEFPRPTLPHVVYVGGI-LTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGV--KYLSDDIA 306

  Fly   311 RILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHY 375
            :.|..|...|||||:|:|......::.:|..:..|:||.|||.....:.|::|||:.|..|::::
Zfish   307 QKLAGALSRLPQRVIWRFSGVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYH 371

  Fly   376 GKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRD 440
            |.|::|:|.|.|.:..:..::..|..:.|.:..|:.::|...::.::|:||:...|::....::|
Zfish   372 GVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKD 436

  Fly   441 QPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSV 505
            ||..|:..||:|..|:|||:||.|:|.|..::..:.:..|||        .:||...||:..:.:
Zfish   437 QPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDV--------AMVIGVCLLLTGYCL 493

  Fly   506 CKISKNISTRL 516
            .:|.|.|..||
Zfish   494 YRIVKFIQFRL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	131/474 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	132/468 (28%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	141/508 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585172
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.740