Protein Alignment Ugt35E1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_652622.3
• Gene: Ugt35E1 / 53504
• FlyBaseID: FBgn0040253
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 159/564 - (28%)
• Similarity: 276/564 - (48%)
• Gaps: 83/564 - (14%)

  Fly     2 LASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKN 66
            ||:||  |::|....:....::|.: |:.. ||:......|:.|.:.||:..
Human    12 LATGL--LLLLSVQPWAESGKVLVV-PIDG-SHWLSMREVLRELHARGHQAV------------- 59

  Fly    67 IYDIYVPEV-LNSFDELLKQMTTPKNTW-------------EFFDATNEFVYNITK--------- 108
               :..||| ::..:|....:||...:|             :.:..|..|:....:
Human    60 ---VLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMS 121

  Fly   109 --------DVFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGL---APCGIDW 162
                    ::.:|:.:.|.:   ....||:::.|.....|.. ||.|...|.:..   .||.:|:
Human   122 LVYHRSCVELLHNEALIRHL---NATSFDVVLTDPVNLCAAV-LAKYLSIPTVFFLRNIPCDLDF 182

  Fly   163 KIDEMVGNPSPMSYLQSPSSYLYNLD--TFGGRVAHVV-EVAISWFNWHWRYEQKHEALYKKYFP 224
            |..:.   |:|.||:  |.....|.|  ||..||.::: .:|:|:. .| .:...:.:|..:.|.
Human   183 KGTQC---PNPSSYI--PRLLTTNSDHMTFMQRVKNMLYPLALSYI-CH-AFSAPYASLASELFQ 240

  Fly   225 KIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEH 289
            :...   :.:|....::.|....|.:..|||.:||::.:||::...: |.|:|:.|.:|..||||
Human   241 REVS---VVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANR-KPLSQEFEAYINASGEH 301

  Fly   290 GVIYFSLGTNVRTKNMVDDRKRILI-EAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLA 353
            |::.||||:.|   :.:.::|.:.| :|.|.:||.|||::......::.:|.::.|||||.|||.
Human   302 GIVVFSLGSMV---SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLG 363

  Fly   354 HPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATI 418
            ||..:.||||.|.....|||..|.||:.:|.|.||..|...::..|..::||..:|||::|:..:
Human   364 HPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENAL 428

  Fly   419 LQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVL 483
            ..::.:|.::.......:.::|:|::||:.||:|..:|:|||||||:|.|...|:::.:|||||:
Human   429 KAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI 493

  Fly   484 GTVLLVILLVIIAILLIIVFSVCKIS--KNISTRLVVKKQRKQK 525
            |.:|.|:|.|     ..|.|..|...  |.:..:..|||..|.|
Human   494 GFLLAVVLTV-----AFITFKCCAYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	129/492 (26%)
		UDPGT	33..484	CDD:278624	137/488 (28%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	148/536 (28%)
		egt	<262..508	CDD:223071	95/254 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150576
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790