Protein Alignment Ugt35E1 and UGT1A9

DIOPT Version :9

• Sequence 1: NP_652622.3
• Gene: Ugt35E1 / 53504
• FlyBaseID: FBgn0040253
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 166/552 - (30%)
• Similarity: 269/552 - (48%)
• Gaps: 76/552 - (13%)

  Fly    11 ILLFPGFLYGARILALFPVP-SHSHYYHALPYLKNLASLGHEITSVSPFPSEE-------PVKNI 67
            :||..||....::|.   || ..||::.....::.|...|||:..|.|..|.:       .||..
Human    16 LLLTCGFAEAGKLLV---VPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTY 77

  Fly    68 YDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNIT----KDVFN----------NDGVRR 118
            ...|   .|...|...|.....:  |:   |....:|::.    .|:|:          .|....
Human    78 STSY---TLEDLDREFKAFAHAQ--WK---AQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLV 134

  Fly   119 EILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSY 183
            |.|:  ::.||.:.:|.:. :....:|.||..|.:..|...:...::|....|:|:||:  |...
Human   135 EYLK--ESSFDAVFLDPFD-NCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYV--PRIL 194

  Fly   184 LYNLD--TFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQ------DI- 239
            |...|  ||..||.:           |..:.::| .|..::|....|.  .|||.|      |:
Human   195 LGFSDAMTFKERVRN-----------HIMHLEEH-LLCHRFFKNALEI--ASEILQTPVTEYDLY 245

  Fly   240 ---ALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVR 301
               ::.|:...|.|..|:|.:||:|.:||::. .|.|.|..:.|.:|..|||||::.||||:.|
Human   246 SHTSIWLLRTDFVLDYPKPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVVFSLGSMV- 308

  Fly   302 TKNMVDDRKRILI-EAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGG 365
              :.:.::|.:.| :|.|.:||.|||::......::.:|.::.|||||.|||.||..:.||||.|
Human   309 --SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAG 371

  Fly   366 MQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVT 430
            .....|||..|.||:.:|.|.||..|...::..|..::||..:|||::|:..:..::.:|.::..
Human   372 SHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKEN 436

  Fly   431 ARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVII 495
            .....:.::|:|::||:.||:|..:|:|||||||:|.|...|:::.:|||||:|.:|.|:|.|
Human   437 IMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV-- 499

  Fly   496 AILLIIVFSVCKIS--KNISTRLVVKKQRKQK 525
               ..|.|..|...  |.:..:..|||..|.|
Human   500 ---AFITFKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	139/484 (29%)
		UDPGT	33..484	CDD:278624	145/484 (30%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	157/533 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150338
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690