Protein Alignment Ugt35E1 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_652622.3
• Gene: Ugt35E1 / 53504
• FlyBaseID: FBgn0040253
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 166/562 - (29%)
• Similarity: 280/562 - (49%)
• Gaps: 80/562 - (14%)

  Fly     4 SGL--FYLIILLFPGFLYGARILALFPVP-SHSHYYHALPYLKNLASLGHEITSVSPFPSEE--- 62
            :||  .|:.:||..||....::|.   || ..||::.....::.|...|||:..|.|..|.:
Human     7 TGLLPLYVCLLLTCGFAKAGKLLV---VPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGR 68

  Fly    63 ----PVKNIYDIYVPEVLNSFDELL----KQMTTP-KNTWEFFDATNEFVYNI----TKDVFNND 114
                .||.....|..|  :...|.:    .:.|.| ::.:....:::..::::    .:.:||:
Human    69 SLNCTVKTYSTSYTLE--DQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFND- 130

  Fly   115 GVRREILRPGKAQFDLIIVDIWKYDAF-YSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQ 178
              |:.:....::.||.:.:|  .:||. ..:|.||..|.:..|.......::|....|:|:||:
Human   131 --RKLVEYLKESCFDAVFLD--PFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYV- 190

  Fly   179 SPSSYLYNLD--TFGGRVAHVVEVAISWFNW-HWRYEQKHEALYKKYFPKIAETKPLSEISQDI- 239
             |...|...|  ||..||            | |..:.::|  |:..||     .|.:.||:.:|
Human   191 -PRLLLGFSDAMTFKERV------------WNHIMHLEEH--LFCPYF-----FKNVLEIASEIL 235

  Fly   240 -------------ALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGV 291
                         ::.|:...|.|..|:|.:||:|.:||::. .|.|.:..:.|.:|..|||||:
Human   236 QTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINC-HQGKPVPMEFEAYINASGEHGI 299

  Fly   292 IYFSLGTNVRTKNMVDDRKRILI-EAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHP 355
            :.||||:.|   :.:.::|.:.| :|.|.:||.|||::......::.:|.::.|||||.|||.||
Human   300 VVFSLGSMV---SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHP 361

  Fly   356 KVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQ 420
            ..:.||||.|.....|||..|.||:.:|.|.||..|...::..|..::||..:|||::|:..:..
Human   362 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 426

  Fly   421 LLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGT 485
            ::.:|.::.......:.::|:|::||:.||:|..:|:|||||||:|.|...|:::.:|||||:|.
Human   427 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 491

  Fly   486 VLLVILLVIIAILLIIVFSVCKIS--KNISTRLVVKKQRKQK 525
            :|.|:|.|     ..|.|..|...  |.:..:..|||..|.|
Human   492 LLAVVLTV-----AFITFKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	138/492 (28%)
		UDPGT	33..484	CDD:278624	142/485 (29%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	154/534 (29%)
		egt	<264..504	CDD:223071	93/248 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150337
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690