DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	158/531 - (29%)
Similarity:	268/531 - (50%)	Gaps:	24/531 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNIYDIYVP- 73
            |::|..| .:||.||.||...|.||....:...:.||..||.:|.|:........|:|..|.||
  Fly    12 IVVLIAG-AHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDINHILVPM 75

  Fly    74 --EVLNSFDELLKQMTTPKNTWEF---FDATNEFVYNITK--DVFNNDGVRREILRPGKAQFDLI 131
              ::|.:|:.::..||...|:..:   |.:..:.....:|  ||.....|:.....|.. :|||:
  Fly    76 EEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETFSKMGDVMKQPLVKDLYEHPDN-KFDLV 139

  Fly   132 IVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDT--FGGRV 194
            :|..:......:||...:.|:: :|.......:..::|||..:||:...|..:.....  ||.||
  Fly   140 MVGYFMNCYQLALAHKLKVPLV-VALSNPPSFLGYLLGNPWEVSYVPGMSVSIKGGKPLGFGHRV 203

  Fly   195 AHVV-EVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQH-FTLGPPRPYV 257
            .::: .:|...|  .:..|.::..:|::.:..........::.::|:|:....| .:.||.||.|
  Fly   204 LNLLGSMAQRLF--MFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFASHGISEGPIRPNV 266

  Fly   258 PNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQ 322
            |.|||:||:.:.|||:.|.|::|.|: ....:|.|..|||:|::..::.....:.:......|.|
  Fly   267 PAVIEIGGIQVKEQPERLPQNMEQFL-SEAPNGAILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQ 330

  Fly   323 RVLWKFEDEELQDIP---SNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPF 384
            :|:||::|  |.:||   .|:|..||:||.|:||||.:.|||||.|.....|:.::|||||.||.
  Fly   331 KVIWKWDD--LDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYHGKPMLALPV 393

  Fly   385 FYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETA 449
            |.||.:|.|.:..|||.:..:...:..|.....|.::|...::....:.....|||:|:.|.||.
  Fly   394 FGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRDRPLSPRETL 458

  Fly   450 VWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNIST 514
            ::|..||:|:.||||::.....:|:...::|||...:|..|:.:.....|:....|.|:.|| |.
  Fly   459 IYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFITKLLFGLVVGKLRKN-SR 522

  Fly   515 RLVVKKQRKQK 525
            :..|.::.|.|
  Fly   523 KAKVNQKHKLK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	139/465 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	137/465 (29%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	155/519 (30%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	142/477 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445803
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950