DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	160/540 - (29%)
Similarity:	273/540 - (50%)	Gaps:	57/540 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVK 65
            |:.....:|::|.......||.||.||...|.||....:...|.|...||.:|.||....:...|
  Fly     1 MIGVHFVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHK 65

  Fly    66 NIYDIYVP---EVLNSFDELLKQMTTPKNTWEFFDATNEFVYNI--TKDVFNNDGVRREIL---- 121
            :|:.|.||   |.....::.:.:|...||      :....:|.:  :.||..|  .:.|:|
  Fly    66 DIHLIVVPMKEEQERIMEDQMTEMAGQKN------SLVSTMYRLLTSMDVMIN--AQAELLSDPR 122

  Fly   122 --RPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDW------KIDEMVGNPSPMSYLQ 178
              |..:.:|||:|:..:..|....:|...:.|:|      |:|      .||:..||||.:||:.
  Fly   123 FQRIYETKFDLMILGYFINDFQLGVAHKLKVPVI------INWMSAPVPAIDKYTGNPSELSYVP 181

  Fly   179 SPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVL 243
            ...:.......|..|..:.::..:..|.: ..::.|...:|...||: .:...|.|:.::|::..
  Fly   182 LMGTVATQPMGFLKRTENALKSLLFEFIF-VVFDYKLTRIYNDVFPE-QDMPTLKELRKNISMAF 244

  Fly   244 VNQH-FTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVD 307
            |..| .:.||.||.||.:||:||:.:.::|..|.:|::.|| .:.:.|.::.|||:||::..:..
  Fly   245 VGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTVRP 308

  Fly   308 DRKRILIEAFGSLPQRVLWKFEDEELQDIP---SNVLVRKWLPQQDLLAHPKVKLFITHGGMQST 369
            :..:|:.:....|.:.|:||:||  |::.|   ||:|.:.||||.|:||||..||||||.|....
  Fly   309 EIVQIIFKVLSELKENVIWKWED--LENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGI 371

  Fly   370 IESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIA 434
            .|:.::|.||:.||.|.||..|...::|.|:.|:|:...:|.|.|:..:.::|..::::......
  Fly   372 TEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQF 436

  Fly   435 GARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILL 499
            ...|||:||...::.|:||.|:|||:|||:::.....::|...::||:.  .|:|.:||:..:|
  Fly   437 STLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIY--ALIVTILVLFVLL- 498

  Fly   500 IIVFSVCKISKNISTRLVVK 519
                          ||||.|
  Fly   499 --------------TRLVAK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	143/475 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	140/471 (30%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	147/484 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	150/508 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445691
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850