DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt37D1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	175/558 - (31%)
Similarity:	283/558 - (50%)	Gaps:	70/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GLFYLIILL--FPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNI 67
            ||...::.|  .|....||.||.:|...|.||:...:..:|.||..||.:|.||..|.:...|:|
  Fly    15 GLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSI 79

  Fly    68 YDIYVP------EVLN-SFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGK 125
            ..|.||      :||| ....::|:..:..||.:...::...:.:...||..:...:...|..|.
  Fly    80 NHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLEDPRFQELYLNKGN 144

  Fly   126 AQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWK------IDEMVGNPS----PMSYLQSP 180
             :||::.|..:......:|.|.|..|:|      |.|.      ::|::|||.    |..::.:|
  Fly   145 -KFDVVFVGFFFNTYQVALGARFNCPVI------ISWSGPPMMMVNEVLGNPELSSVPQMHISAP 202

  Fly   181 SSYLYNLDTFGGRVAHVVEV----AISWFNWHWRYEQKHEALYK--KYFPKIAETKPLSEISQDI 239
            .....|   |..|:.:....    |::.|..| :|.:.::.|:.  |..|..|:.|      :::
  Fly   203 PGQPMN---FQQRMQNFASTLGFNALNIFLNH-KYNKFYDRLWSKDKSMPTFAQAK------RNV 257

  Fly   240 ALVLVNQH-FTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTK 303
            :|...|.| .:.||.||.||.|||:||:.:..:|..|.:|:::|:: .|:||.|.||||:|::.:
  Fly   258 SLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLKGE 321

  Fly   304 NMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIP---SNVLVRKWLPQQDLLAHPKVKLFITHGG 365
            ::..:..:.:.:...||.|:|:||:||.  ::.|   :|:|.:|||||.|:|||||:||||||.|
  Fly   322 HIQPEVVKTIFKGLSSLKQQVIWKWEDP--KNTPGKSANILYKKWLPQDDILAHPKLKLFITHAG 384

  Fly   366 MQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVT 430
            .....|:.::|.|||.||.|.||..|.|.:...|:.|.|....:..||.||.|.:::...::..|
  Fly   385 KGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKT 449

  Fly   431 ARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVII 495
            .:.....|||:|:.|.|:.|:||.||:||.||.||:.....::|...::||:         .:|.
  Fly   450 LKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDI---------YIIA 505

  Fly   496 AILLIIVFSVCKI------------SKNISTRLVVKKQ 521
            |::|.|||.:.||            |..:|....||||
  Fly   506 ALVLYIVFIINKIVWKFVWRKLFGKSNKVSKGKKVKKQ 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	153/483 (32%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	151/477 (32%)
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	161/515 (31%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	159/513 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445705
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950