DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	196/538 - (36%)
Similarity:	310/538 - (57%)	Gaps:	39/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLIILLF------PGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKN 66
            :|.:|||      ..:.|    |.:....:.|||:......|.||:.||::|.:|||..::|:||
  Fly    10 FLALLLFCLLSCVSAYNY----LVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKN 70

  Fly    67 IYDIYVPEVLNSFD----ELLKQMTTP--KNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGK 125
            |.|:....:|.|..    .||:....|  |....|    :|....||:.:.....| .|:::..:
  Fly    71 IKDVPAKSILTSMQGRIANLLQSSKEPIIKQIINF----HEMGIEITELLLKEPSV-IELMKSNQ 130

  Fly   126 AQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCG-IDWKIDEMVGNPSPMSYLQSPSSYLYNLDT 189
            . ||.:|.:::..:|.:..|.:|:||:|||...| |.|..| :||:|||.||:  ||:.|...|.
  Fly   131 T-FDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTD-LVGSPSPPSYV--PSALLKFSDR 191

  Fly   190 FG--GRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGP 252
            ..  .||.:...:...:...::.|..:.|.||:||||.  ..:...::.::.||||:|||.:|..
  Fly   192 MSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPN--NKQDFYDMRKNTALVLLNQHVSLSF 254

  Fly   253 PRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAF 317
            ||||.||:||||||||:.:.:.|.:|:.:||:|: ||||||||:|:|:::|.:..::::.||:.|
  Fly   255 PRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTF 318

  Fly   318 GSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGL 382
            ..|.|||||||||.:|...|:||.:..|.||.|:|||..|..||||||:.||.|||::.||.:|:
  Fly   319 AQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGI 383

  Fly   383 PFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLE 447
            |.|.|||.|:...:::|:.::::|.:::|.:|.|.|.:::.........|....|||||...|||
  Fly   384 PIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLE 448

  Fly   448 TAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNI 512
            .||:|..:|.|||||.::|.|.:.|:|..:|:||.     ::||...|..:|..:|.:.::...:
  Fly   449 RAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDA-----MLILYGGIIFVLYCIFLLIRLVWRL 508

  Fly   513 STRLVVKK---QRKQKVR 527
            ...|.:||   :.|||.:
  Fly   509 LQELFIKKDTSKPKQKAK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	175/467 (37%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	179/459 (39%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	145/356 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445622
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800