DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	189/542 - (34%)
Similarity:	292/542 - (53%)	Gaps:	46/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGLFYLIILLF----PGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPV 64
            :||. |.:|||    |.......|||:|.....|.|....|:|:||...||::|.:|.......:
  Fly     8 AGLL-LTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHI 71

  Fly    65 KNIYDIYVPEVLNSFDELLK-----QMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPG 124
            :.::.|.||::    |.|:|     :..|....|......:|:.||.:|.|..:.|| :|:||..
  Fly    72 EGVHHIRVPKL----DMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGV-QELLRNA 131

  Fly   125 KAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYL-YNLD 188
            .|::.|||::....||.|..:.:|.||::|:|..|..|.||.:|||.:|..|  .|.|.| |
  Fly   132 SAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVY--EPMSALGY--- 191

  Fly   189 TFGGRVAHVVEVAISWFNWH-------------WRYEQKHEALYKKYFPKIAETKPLSEISQDIA 240
            |.|   .:::|      .||             :.|..:...|||::||  ..|..:.::.:..:
  Fly   192 TSG---LNLIE------KWHNLIYITEERLVERFIYLPRQIDLYKQHFP--GATTSIHDLRRRFS 245

  Fly   241 LVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNM 305
            |||:|||||:|..|..|||::||.|||:||:|..|..:|:..:. ..||||||||:|..:....:
  Fly   246 LVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-EAEHGVIYFSMGLQLLDHWL 309

  Fly   306 VDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTI 370
            ....:..:.:||..|.|:|:||.:..|:.:...||..|.|.||:.:|.||.|||||||.|:.|.|
  Fly   310 PPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLI 374

  Fly   371 ESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAG 435
            ||:||..|:|.:|.|||||.|...::|.|....|::.::..||:...|..|:....::..||...
  Fly   375 ESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLS 439

  Fly   436 ARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLI 500
            .|:.||||..::||:|||.|:||||||.|||:|.:::|...::::||:..:...|.|..|.::.:
  Fly   440 QRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFL 504

  Fly   501 IVFSVCKISKNISTRLVVKKQR 522
            ....|...::::..||.|...|
  Fly   505 GWKLVSLATRHLEYRLNVPMVR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	170/477 (36%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	170/469 (36%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	164/460 (36%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	173/489 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445590
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800