DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	140/533 - (26%)
Similarity:	255/533 - (47%)	Gaps:	59/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHE-----ITSVSPFPSEEPVKN 66
            :::::....|....|:|:.:.|:...||.|    ..|.|||..||     :..:|.....:| .|
  Rat     7 YFMLLWSAVGIARAAKIIIVPPIMFESHLY----IFKTLASALHERGHHTVFLLSEGRDIDP-SN 66

  Fly    67 IYDIY-VPEVLNSFDELLKQMTTPKNTW-------EFFDATNEFVYNITKDVFNN---DGVRREI 120
            .|.:. .|.:.||........:..:|.:       |..|..:.:..|....|.|.   .|:::|
  Rat    67 HYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKE- 130

  Fly   121 LRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLA----PCGIDWKIDEMVGNPSPMSYLQSPS 181
                  :|||::||.      ..:..:..|.::|:.    ..|: |...| ||.|:|::|:...:
  Rat   131 ------KFDLLLVDP------NDMCGFVIAHLLGVKYAVFSTGL-WYPAE-VGAPAPLAYVPEFN 181

  Fly   182 SYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQ 246
            |.|.:...|..|:.:.....||.....:....|:|.:.:||  .:...|.:.::....:|.::..
  Rat   182 SLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKY--NLLPAKSMYDLVHGSSLWMLCT 244

  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKR 311
            ...|..|||.:|||:.|||: :.:....|.:||:.::.|:.|||.:..|.|..|  |.:.:|...
  Rat   245 DVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGV--KYLSEDIAN 306

  Fly   312 ILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376
            .|..|.|.|||:|:|:|...:.:::.:|..:.:||||.|||.|..::.|::|||:.|..|::::|
  Rat   307 KLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHG 371

  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQ 441
            .|::|:|.|.|.:..:..::..|..:.|.::.:|..||...:::::....:...|:.....::||
  Rat   372 VPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQ 436

  Fly   442 PMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLII----- 501
            |..|:....:|..|:|||.||.|:|.|..::||..:..||    :..|:||..:|:..|:
  Rat   437 PGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLD----IAFVLLLGAVALYFIVSYVTK 497

  Fly   502 -----VFSVCKIS 509
                 |.|:|..|
  Rat   498 FIYRKVKSLCSRS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	122/473 (26%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	127/470 (27%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	135/510 (26%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	135/509 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344182
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740