DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	170/563 - (30%)
Similarity:	277/563 - (49%)	Gaps:	77/563 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSP--------- 57
            :.:.|..|.:.:|.|...|.::| ::|| ..||:.:....|..|...|||:..:.|
  Rat     5 MTAALLLLHLTIFFGSGSGGKVL-VWPV-EFSHWLNLKIILSELVKKGHEVVVLKPSVSFSYEVD 67

  Fly    58 ---------FPSEEPVKNIYDIYVPEVLNSFDELLKQMTTPKNTW-------EFFDATNEFVYNI 106
                     |||...:.::..|::..|..|..||.||     :.|       :.|:.|:::...:
  Rat    68 KTSAIEFESFPSSYSIADVEVIFMDCVNESIYELPKQ-----SFWGYFLMLQKLFERTSDYSERL 127

  Fly   107 TKDVFNNDGVRREILRPGKAQFDLIIVD-----------IWKYDAFYSLAAY----FEAPIIGLA 156
            .:|...|..:..::...|   ||:|:.|           |.|....|||..:    :|....||
  Rat   128 CRDAAFNKELMTKLQNSG---FDVILADPFTPCGDLLAEILKIPLVYSLRFFPGSTYEKYSGGL- 188

  Fly   157 PCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKK 221
                          |.|.||:....|.|.:..||..||.|::.|....|.:....|:|...||.:
  Rat   189 --------------PMPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQVFDEKKWNELYTE 239

  Fly   222 YFPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGS 286
            .   :.....|||......:.|:..::.|..|.|.:||...|||:|. ...|.|.:::|||:|.|
  Rat   240 V---LGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHC-RPAKPLPKEIEDFVQSS 300

  Fly   287 GEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDL 351
            |||||:.||||:.|  .::.::|..::......:||:|||:||.::.:.:.||..:.||:||.||
  Rat   301 GEHGVVVFSLGSMV--GSLTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDL 363

  Fly   352 LAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKA 416
            |.|||.:.||||||.....|:|::|.|::|:|.|.||..|:.|:|..|..:.|::..|:|.:|..
  Rat   364 LGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTDLLT 428

  Fly   417 TILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLD 481
            .:..:..:..::..|......:.|||:|||:.||:|..:|:|||||.|:||||..||:..:||||
  Rat   429 ALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYHSLD 493

  Fly   482 VLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQ 524
            |:|.:|..::.|:..:....:|...|.:|      ..:|::|:
  Rat   494 VIGFLLACVVTVMFILKKCCLFCCQKFTK------AGRKKKKE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	147/494 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	154/490 (31%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	163/539 (30%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	98/240 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344065
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690