DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	166/560 - (29%)
Similarity:	267/560 - (47%)	Gaps:	74/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGLFYLI--ILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPV-- 64
            ||::.|:  .:...|..:||.||.:|...|.||....:...|.||..||.:|.::..   :||
  Fly     5 SGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL---KPVVN 66

  Fly    65 -KNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATN------------EFVYNITKDVFNNDGV 116
             |||..|.||..    .|..:||:.........|.:|            ||:::.......:|.|
  Fly    67 HKNITVIMVPLT----KEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRV 127

  Fly   117 RREIL-RPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSP 180
            |...| |..|  |||::...:........|...:||:|.:|....:..::.::|||..::|:.|.
  Fly   128 RDLYLNRDNK--FDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSI 190

  Fly   181 SSYL--------------YNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKP 231
            |..:              |:...|.|....|.             :::.:.|||:.|........
  Fly   191 SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVT-------------QRRSKRLYKELFGDDPNMPE 242

  Fly   232 LSEISQDIALVLVNQHF-TLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFS 295
            .||:.::.:|:....|. :.||.||.||..||:||:.:.:.|..|.|::.:|: |:...|.|..|
  Fly   243 YSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLS 306

  Fly   296 LGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIP---SNVLVRKWLPQQDLLAHPKV 357
            ||:||:..::..|....:......|.|||:||:||  |:..|   .|:...|||||.|:||||.:
  Fly   307 LGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWED--LEKTPGKSDNIFYSKWLPQDDILAHPNI 369

  Fly   358 KLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLL 422
            ||||.|.|.....|:.::|||||.||.|.||..|.|.:.|.||.|:.:...:.....|..||::|
  Fly   370 KLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEIL 434

  Fly   423 TEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDV--LGT 485
            :..::........:.|||:||...|:.::||.||:||.||.|::.....:||...:::|:  |..
  Fly   435 SNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIA 499

  Fly   486 VLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQK 525
            |:||||::::.:||..::           |.:..|.:|:|
  Fly   500 VVLVILVLLLKLLLQFIY-----------RKIFAKPKKEK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	146/490 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	144/486 (30%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	151/506 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445719
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950