DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	210/539 - (38%)
Similarity:	317/539 - (58%)	Gaps:	31/539 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVK 65
            :|..||.:|........:..:||||:||.|..|.|..|..::|.||..||.:|.::.|.|::...
  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEP 76

  Fly    66 NIYDI---YVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQ 127
            |...|   .:.|::.:|..  ...|...:.|:....|.:|:..:|..:. :|...:::|..|: :
  Fly    77 NFRVIGAKKIHEIMAAFGN--ADYTQTASQWQMLTMTTQFLNLLTTSIL-DDAAVKDLLNSGE-K 137

  Fly   128 FDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSP---SSYLYNLDT 189
            |||:|::..:.:|.:.|..:|.|..||::..|.|..|||::||.||:||  :|   ||....:|
  Fly   138 FDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSY--NPLLLSSRTEQMD- 199

  Fly   190 FGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPPR 254
            |..||.:|.|.::.|.:....:......||.||||  ...|.|.|:....||:|:.|||:|..||
  Fly   200 FKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFP--TARKSLDEVLDSFALMLLGQHFSLSYPR 262

  Fly   255 PYVPNVIEVGGMHIDEQPKA--LAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAF 317
            ||:||:|||||:|:.::.|.  ||::|.:|::.| |.||||||:|:|:::|::....:::|::.|
  Fly   263 PYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTF 326

  Fly   318 GSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGL 382
            .|:||||||||||::|.:.|.||.:.||.||.|:||||.|||||||||:.||||||::|||:|||
  Fly   327 ASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGL 391

  Fly   383 PFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLE 447
            |.||||..||...|:.|:.||.:...:.:.||...|.:||:...:...|:.....:|||....||
  Fly   392 PIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALE 456

  Fly   448 TAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC------ 506
            .|:|||.||||||||.|:|.|.|.|.|...|.||..|   |:|.:..:::|::::...|
  Fly   457 RAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWG---LLIAITFVSLLIVVILIKCLQRVFV 518

  Fly   507 ----KISKNISTRLVVKKQ 521
                ||.||.:....:|.|
  Fly   519 SLISKIRKNRAEASKLKTQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	185/462 (40%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	188/458 (41%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	187/464 (40%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	191/483 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445575
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.800