DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	261/501 - (52%)
Similarity:	360/501 - (71%)	Gaps:	4/501 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVK 65
            |||..:.:|::.| |..:..|||||:||.|..|.|.:.:||||.||:.||::|||:.||.::||.
  Fly     1 MLALRIGFLLLTL-PASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV 64

  Fly    66 NIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDL 130
            |..|:::|:|.|::.||:.:::.|.|.|:..:..|:|..::|:.|..|..|...:|.|||..|||
  Fly    65 NFRDVFIPDVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPGKDHFDL 129

  Fly   131 IIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVA 195
            |||:..:.||:|..||:|.|||||::..|.||.||.:|||.||:||....:..|.:..||..|::
  Fly   130 IIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRMTFLERLS 194

  Fly   196 HVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNV 260
            :.|:..::|.|:.:.:..:.|.:|.||||:.::...|::::::.:|||:||||:|..|||||||:
  Fly   195 NFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNM 259

  Fly   261 IEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVL 325
            |||||:||..:|..|.:|||:||||||||||||||||:||.:|::..|||.::::.|.|||||||
  Fly   260 IEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVL 324

  Fly   326 WKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFT 390
            |||||::|...||||.:.||.||.|:||||||||||||||:.|||||||:|||:||||||||||.
  Fly   325 WKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFL 389

  Fly   391 NVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHY 455
            ||....:.||.|.|::..||..|||.||..||.|.||...||....|||||||.||:||:|||.|
  Fly   390 NVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEY 454

  Fly   456 VLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVL---LVILLVIIAIL 498
            |||||||.||||||:.|.||.:|||||:|.:|   |:::.:|:.:|
  Fly   455 VLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVGVL 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	236/454 (52%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	242/450 (54%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	241/458 (53%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	210/411 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445571
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55476at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.800