DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	166/571 - (29%)
Similarity:	281/571 - (49%)	Gaps:	101/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSP----------- 57
            |||..|:..|  .:..|.::| :||:.. ||:......::.|.:.||:...::|
  Rat    13 SGLLLLLCAL--PWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDF 73

  Fly    58 -------FP--SEEPVKNIYDIYVPEVLNSFDELLKQMTTPKNTWE-------FFDATNEFVY-N 105
                   ||  .||        |..|:|.:..:..:.....|..:|       |||     :| |
  Rat    74 FTLQTYAFPYTKEE--------YQREILGNAKKGFEPQHFVKTFFETMASIKKFFD-----LYAN 125

  Fly   106 ITKDVFNNDGVRREILRPGKAQFDLIIVD-IWKYDAFYSLAAYFEAPIIGL---APCGIDWKIDE 166
            ....:.:|..:.:::   ..:.||:::.| ::...|.  ||.|.:.|.:..   .|||||::..:
  Rat   126 SCAALLHNKTLIQQL---NSSSFDVVLTDPVFPCGAL--LAKYLQIPAVFFLRSVPCGIDYEATQ 185

  Fly   167 MVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAET-- 229
            .   |.|.||:.:..:.|.:..||..||.:::                 ..|..||...::.|
  Rat   186 C---PKPSSYIPNLLTMLSDHMTFLQRVKNML-----------------YPLTLKYICHLSITPY 230

  Fly   230 -KPLSEISQ-DIALVLVNQH---------FTLGPPRPYVPNVIEVGGMH-IDEQPKALAQDLEDF 282
             ...||:.| :::||.|..|         |....|||.:||::.:||:: :.::|  |:|:.|.:
  Rat   231 ESLASELLQREMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKP--LSQEFEAY 293

  Fly   283 IQGSGEHGVIYFSLGTNVRTKNMVDDRKRI-LIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWL 346
            :..|||||::.||||:.|   :.:.::|.: :.||.|.:||.|||::......::..|.::.|||
  Rat   294 VNASGEHGIVVFSLGSMV---SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWL 355

  Fly   347 PQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTS 411
            ||.|||.|||.:.||||.|.....|.|..|.||:.:|.|.||..|...::..|..::||..:||:
  Rat   356 PQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTA 420

  Fly   412 DELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFT 476
            |:|:..:..::..|.::.......:.::|:|::||:.||:|..||:|||||||:|.|...|:::.
  Rat   421 DDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQ 485

  Fly   477 HHSLDVLGTVLLVILLVIIAILLIIVFSVCKIS--KNISTRLVVKKQRKQK 525
            :|||||:|.:|.::|.|:     .||:..|...  |....:..|||..|.|
  Rat   486 YHSLDVIGFLLAIVLTVV-----FIVYKSCAYGCRKCFGGKGRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	138/501 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	144/497 (29%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	155/545 (28%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	94/255 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860