DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt1a6b

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_958812.3	Gene:	Ugt1a6b / 394435	MGIID:	3580629	Length:	531	Species:	Mus musculus

Alignment Length:	588	Identity:	171/588 - (29%)
Similarity:	279/588 - (47%)	Gaps:	133/588 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASGLFYLIILLFPGFLYGARILA--LFPVPSH-SHYYHALPYLKNLASLGHEITSVSPFPSEEP 63
            |.:|..:|::        .|.:|.  |..||.. ||:......:::|:..||:|.
Mouse    11 LPAGFLFLVL--------WASVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIV---------- 57

  Fly    64 VKNIYDIYVPEV-------------LNSFDELLKQMTTPKNTWEFFDATNEFV-----------Y 104
                  :.||||             :.|....|:::.|...|:    ..|:||           |
Mouse    58 ------VLVPEVNLLLGESKYYRRKIFSVPYSLEELQTRFRTF----GRNQFVPGAPLMGPLREY 112

  Fly   105 N---ITKDVFNN-------DGVRREILRPGKAQFDLIIVDIWKYDAFYS---------LAAYFEA 150
            .   :|.::|.:       |......||..            |:||.::         ||.|...
Mouse   113 RNSMLTLEMFFSNCQSLLKDSATLSFLREN------------KFDALFTDPAMPCGVILAEYLNL 165

  Fly   151 PIIGL---APCGIDWKIDEMVG-NPSPMSYLQSPSSYLYNLD--TFGGRVAH-VVEVAISWFNWH 208
            |.:.|   .||    .::.|:| :|||:||:  |..|....|  ||..|:|: :|.:..::.
Mouse   166 PSVYLFRGFPC----SLEHMLGQSPSPVSYV--PRFYTKFSDHMTFPQRLANFIVNILENYL--- 221

  Fly   209 WRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQH--------FTLGPPRPYVPNVIEVGG 265
                  :..||.||  :|..|..|   .:|::|..::|:        |....|||.:||:|.:||
Mouse   222 ------YYCLYSKY--EIIVTDLL---KRDVSLPSLHQNSLWLLRYDFVFEYPRPIMPNMIFIGG 275

  Fly   266 MHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRI-LIEAFGSLPQRVLWKFE 329
            ::..::.| |.|:.|.::..|||||::.||||:.|   :.:.::|.: :.||.|.:||.|||::.
Mouse   276 INCKKKGK-LTQEFEAYVNASGEHGIVVFSLGSMV---SEIPEKKAMEIAEALGRIPQTVLWRYT 336

  Fly   330 DEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDH 394
            .....::..|.::.|||||.|||.|||.:.||||.|.....|.|..|.||:.:|.|.||..|...
Mouse   337 GTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKR 401

  Fly   395 IKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRH 459
            ::..|..::||..:||:|:|:..:..::..|.::.......:.::|:|::||:.||:|..||:||
Mouse   402 METRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRH 466

  Fly   460 KGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKIS--KNISTRLVVKKQR 522
            |||||:|.|...|:::.:|||||:|.:|.::|.|:     .|||..|...  |....:..|||..
Mouse   467 KGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVV-----FIVFKCCAYGCRKCFGGKGRVKKSH 526

  Fly   523 KQK 525
            |.|
Mouse   527 KSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	142/516 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	149/509 (29%)
Ugt1a6b	NP_958812.3	egt	15..503	CDD:223071	159/556 (29%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	161/555 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840669
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690