DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	175/519 - (33%)
Similarity:	290/519 - (55%)	Gaps:	27/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPF--PSEEPVKNIYDIYVPEVLNSFDEL 82
            |:||||.|..|..||:......::.|...|||:|.::||  ..|:...|..:|.:|:.  .|...
  Fly    25 GSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKEIVIPQY--DFWPE 87

  Fly    83 LKQMTTPKN---------TWEFFDATNEFVYNITKDVFNNDGVRREILRPGK-AQFDLIIVDIWK 137
            :|:||. ||         |:.|....|....:.|........::..|....| .::||::.:.:.
  Fly    88 IKEMTN-KNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFF 151

  Fly   138 YDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLD--TFGGRVAHVVEV 200
            .:....|...::.|.|.::..|....:.::.|..||.||:  |.:|:...|  |...|:.:|...
  Fly   152 NEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYV--PHAYMPYTDRMTLWERIGNVAMS 214

  Fly   201 AISWFNWHWRYEQKHEALYKKYFPKIAETKP-LSEISQDIALVLVNQHFTLGPPRPYVPNVIEVG 264
            |.......:.|....:|:.||:|.|:.:..| :.|:.::|:.:|:|.:..|...||...|:|.||
  Fly   215 AAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVG 279

  Fly   265 GMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFE 329
            |:|| :.||||.:.|:.|:.|: .||.||||||:.||:.::..::.::.:|.||||.||||||||
  Fly   280 GLHI-QPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFE 342

  Fly   330 DEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDH 394
            ||.|.::|:||.|:.||||.|:||||.||:||.|||:..|.|:::.|.|:||:|.:.||..|::.
  Fly   343 DESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQ 407

  Fly   395 IKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRH 459
            .|...:.|.|:|..:|.:||:..:::|:...::....:.|...:||:|:..::||::|.:||:.|
  Fly   408 GKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEH 472

  Fly   460 KGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRK 523
            :||||:..||..|.::..:.||::|..|.||||.|:.::||     |:.|....:....||.:|
  Fly   473 RGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILI-----CRRSSKPKSTPTKKKTKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	152/455 (33%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	154/465 (33%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	168/494 (34%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	163/488 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454703
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790