DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt36D1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	166/534 - (31%)
Similarity:	287/534 - (53%)	Gaps:	49/534 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGA----RILALFPVP--SHSHYYHALPYLKNLASLGHEITSVSPFPSEEPV 64
            ||..:.|..|..|..|    ::|.|||.|  ||.|::|  |.:|.||..||:::.||.||.:.||
  Fly     9 LFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFH--PIMKGLAEAGHDVSVVSHFPDKHPV 71

  Fly    65 KNIYDI---YVPEVLNSFD-ELLKQMTTPKNTWEFFDATNEFVYNITKDVFN----NDGVRREIL 121
            .:..|.   .:.::.||.| :..::.|...:..|||     .:|:..|...|    ::.:::.:.
  Fly    72 AHYKDFPLTGMDKLTNSVDLKFFEKRTFYSHFQEFF-----LLYDWGKQTCNLTLRSEALQQILR 131

  Fly   122 RPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPC-GIDWKIDEMVGNPSPMSYLQSPSSYLY 185
            |||:  ||:||::.:..|....:|...:||:|.|:.| .:.|..:.| |.|...|::  |:.::.
  Fly   132 RPGR--FDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERM-GAPLIPSHI--PALFMA 191

  Fly   186 NLD--TFGGRVAHVVEVAISWFNWH---WRYE----QKHEALYKKYFPKIAETKPLSEISQDIAL 241
            ...  .||||:|       :||:.|   |.|:    ...:|:.:..|..  :...:.|:.::.::
  Fly   192 QSQHMNFGGRLA-------NWFSTHALNWMYKLLSVPAADAMVQYKFGH--DVPSVGELVKNTSM 247

  Fly   242 VLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMV 306
            ..||||::|..|:...|||||:||:|| ::.|.|..||:..:. :.|.|||..|.|:.:|..::.
  Fly   248 FFVNQHYSLSGPKVTPPNVIELGGIHI-QKSKPLPADLQRILD-NAEEGVILISWGSMIRANSLS 310

  Fly   307 DDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIE 371
            ..::..:|.|...|.|:|:||:|:|.|.:.|.|:.:.|||||:|:|.||.||:|::|||:..|.|
  Fly   311 AAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSE 375

  Fly   372 SIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGA 436
            :.:.|.|::..|.:.|||.|...:.:.|....||:.|:..:.:...:.:.| :|:|...|::...
  Fly   376 AAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKVVSH 439

  Fly   437 RYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLII 501
            .:..:|.:.|.||:||..:|....|||.::.:..::|.|.::||||. .||.::|..|||..:.:
  Fly   440 SFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVY-AVLALVLGSIIASWVWL 503

  Fly   502 VFSVCKISKNISTR 515
            :...|..|....|:
  Fly   504 LRLCCGSSAAQKTK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	148/478 (31%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	144/468 (31%)
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	149/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454591
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890