DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt307A1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_609097.2	Gene:	Ugt307A1 / 33993	FlyBaseID:	FBgn0031887	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	136/528 - (25%)
Similarity:	235/528 - (44%)	Gaps:	104/528 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ILALFPVPSHSHYYHALPYLKN---------------LASLGHEITSVSPFPSEEP--VKNIYDI 70
            :||..|.|..||  |.|....|               |...||.:|.|:..|.||.  ..|:..|
  Fly    20 LLADSPAPVESH--HILGLFVNVHRSQLMVHLAVCRALLQRGHHLTLVTTLPLEEQEIQGNVSHI 82

  Fly    71 YVP-----EVLNSFDELLK-------------QMTTPKNTWEFFDATNEFVYNITKDVFNNDGVR 117
            |:|     |.::|.|.:|:             .:..|:  |:.|                   :|
  Fly    83 YIPWQQPKEEVSSSDLILRLERMFRRLEHSGDLLDLPE--WKMF-------------------LR 126

  Fly   118 REILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLA---PCGIDWKIDEMVGNPSPMSYLQS 179
            .:...|    :||:::.....|....:||:|..|:..::   |.|.   ::.::|||....|:..
  Fly   127 NQPNTP----YDLLLLGYHFNDHLLGVAAHFNCPVAIVSTQQPTGF---VNSLMGNPEERWYVPQ 184

  Fly   180 PSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEAL--------YKKYFPKIAETKPLSEIS 236
            |         :.|:....:.   :|....|  |:..|.|        |:.:||: .:......:.
  Fly   185 P---------YDGQQRSGIS---AWVFGMW--EKFMEILARRVLARIYRLHFPE-PQYPSFETMR 234

  Fly   237 QDIALVLVNQH-FTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNV 300
            :.:.|.|.|.| .:.||..|.:|:::::||:.:::|......::     .:|...:|.|||||..
  Fly   235 RSVVLALSNHHMISEGPIAPLIPSMVDIGGIVLEQQLDKTPLEI-----SAGNRSLIIFSLGTRF 294

  Fly   301 RTKNMVDDRKRILIEAFGSLPQ-RVLWKFEDEE----LQDIPSNVLVRKWLPQQDLLAHPKVKLF 360
            ..:....:..|...:||...|. .:.|.::...    ..|.| ::.|.||.||..:....||:||
  Fly   295 TWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYP-HLKVAKWWPQTQMWQSGKVRLF 358

  Fly   361 ITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEK 425
            |||||..|..|::.||.||||||...||..|:..::...:.|:|:.:::|..:|...|.::|::.
  Fly   359 ITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAITRMLSDS 423

  Fly   426 RFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVI 490
            .:..|...|...|||:|:.|.:...:|..|::|||||.::....|:|:...:||:||. .::..:
  Fly   424 SYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVY-FIVYGL 487

  Fly   491 LLVIIAIL 498
            |::.||||
  Fly   488 LILTIAIL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	122/489 (25%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	127/502 (25%)
Ugt307A1	NP_609097.2	egt	13..492	CDD:223071	132/523 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445775
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950