DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	169/558 - (30%)
Similarity:	270/558 - (48%)	Gaps:	82/558 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIILLF--PGFLYGARILALFPVP-SHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNI--- 67
            |.:.||  .||....|:|.   || ..||::.....::.|:..|||:..|.|..|....|::
  Rat    12 LCVCLFLASGFAQAGRLLV---VPMDGSHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFT 73

  Fly    68 ---YDI-YVPEVLNSFDELLKQMTTPKNTWE----------------FFDATNEFVYNITKDVFN 112
               |.: |..|.||...:....     |.|:                ||    |.:::..:.:|
  Rat    74 VKTYSVSYTLEDLNYHFKFFAH-----NQWKTQEVGMFSLLKHSGKGFF----ELLFSHCRSLF- 128

  Fly   113 NDGVRREILRPGKAQFDLIIVDIWKYDAF-YSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSY 176
            .|....|.|:  ::.||.:.:|  .:|.. ..||.||..|.:..:.......:||....|||.||
  Rat   129 KDKKLVEYLK--QSSFDAVFLD--PFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSY 189

  Fly   177 LQSPSSYLYNLDTFGGRVAHVVEVAISWFNW-HWRYEQKHEALYKKYFPKIAETKPLSEISQ--- 237
            :....|...:..||..||            | |..|.:  |..:..||.|.| .:..||:.|
  Rat   190 VPRILSKFTDTMTFKERV------------WNHLSYMK--ERAFCPYFFKTA-VEIASEVLQTPV 239

  Fly   238 -------DIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFS 295
                   .:::.:....|.|..|||.:||::.:||::. .|.|.|:::.|.::..|||||::.||
  Rat   240 TMRDLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINC-HQGKPLSKEFEAYVNASGEHGIVVFS 303

  Fly   296 LGTNVRTKNMVDDRKRI-LIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKL 359
            ||:.|   :.:.::|.: :.||.|.:||.|||::......::..|.::.|||||.|||.|||.:.
  Rat   304 LGSMV---SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARA 365

  Fly   360 FITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTE 424
            ||||.|.....|.|..|.||:.:|.|.||..|...::..|..::||..:||:|:|:..:..::..
  Rat   366 FITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINN 430

  Fly   425 KRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLV 489
            |.::.......:.::|:|::||:.||:|..||:|||||||:|.|...|:::.:|||||:|.:|.:
  Rat   431 KSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAI 495

  Fly   490 ILLVIIAILLIIVFSVCKIS--KNISTRLVVKKQRKQK 525
            :|.|:     .||:..|...  |....:..|||..|.|
  Rat   496 VLTVV-----FIVYKSCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	143/490 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	147/486 (30%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	159/535 (30%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	93/249 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860