DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	158/532 - (29%)
Similarity:	265/532 - (49%)	Gaps:	76/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHYYHALPYLKNLASLGHEITSVSP--FPSEEPVKNI---YDIY-----VPEVLNSFDELLKQMT 87
            ||:.:....|..|...|||:|.:.|  :...:|.|:.   ::|:     ..|:.|.|.:||...|
  Rat    34 SHWMNIKIILDELVQRGHEVTVLKPSAYFFLDPKKSSDLKFEIFSTSISKDELQNHFIKLLDVWT 98

  Fly    88 --TPKNT------------WEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDL-------- 130
              .|::|            :||    :.|..:|.||..:|   ::.:.:..:::||:
  Rat    99 YELPRDTCLSYSPILQNLVYEF----SYFYLSICKDAVSN---KQLMTKLQESKFDVLFADPVAS 156

  Fly   131 ---IIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN-PSPMSYLQSPSSYLYNLDTFG 191
               :|.::......|||:         .:|   ..|:::.:|. ..|.||:....|.|....||.
  Rat   157 CGDLIAELLHIPFLYSLS---------FSP---GHKLEKSIGKFILPPSYVPVILSGLAGKMTFI 209

  Fly   192 GRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPPRPY 256
            .||.::  :.:.:|:: |....:|:.....|...:.....:.|....:.:.|:..::.|..|.|.
  Rat   210 DRVKNM--ICMLYFDF-WFEILRHKEWDTFYSEILGRPTTVDETMSKVEIWLIRSYWDLKFPHPT 271

  Fly   257 VPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLP 321
            :|||..:||:|. :..|.|.:|:|:|:|.||||||:.||||:.|  .||.:::...:..|...:|
  Rat   272 LPNVDYIGGLHC-KPAKPLPKDMEEFVQSSGEHGVVVFSLGSMV--SNMTEEKANAIAWALAQIP 333

  Fly   322 QRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFY 386
            |:|||||:.:....:..|..|.|||||.|:|.|||.|.|:||||.....|:|::|.||:|:|.|.
  Rat   334 QKVLWKFDGKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPLFG 398

  Fly   387 DQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVW 451
            ||..|:.|:...|..:|||...|:..:..:.:.:::....::....:....:.|||||||:.||:
  Rat   399 DQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRAVF 463

  Fly   452 WTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLG---TVLLVILLVIIAILLIIVFSVCKISKNIS 513
            |..:::|||||.|:|..|..|.::.:|||||:|   |...||..:.:..||.:.
  Rat   464 WIEFIMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLLFMY----------- 517

  Fly   514 TRLVVKKQRKQK 525
             |..|||::|.|
  Rat   518 -RFFVKKEKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	134/463 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	146/486 (30%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	156/529 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860