DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	522	Identity:	148/522 - (28%)
Similarity:	258/522 - (49%)	Gaps:	57/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHYYHALPYLKNLASLGHEITSVSPF------PSEEP---VKNIYDIYVPEVLNSF-DELLKQMT 87
            ||:.:....|..|...|||:|.:.|.      |...|   .:.....:..:.|.:| .:|:.:.|
Mouse    34 SHWMNLKIILDELVQRGHEVTVLRPSASIFVDPKYSPGLKFETFPTAFSKDYLETFLTKLVDEWT 98

  Fly    88 --TPKNT-------WEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYS 143
              .|::|       ...|...:::..::.|:..:|   ::.:.:..:::||::|:     ||..|
Mouse    99 FEVPRDTCLSYSLLQTLFGKLSDYSLSLCKEAVSN---KQLMTKFQESKFDVLIL-----DAMAS 155

  Fly   144 ----LAAYFEAPIIGLAPCGIDWKIDEMVGN-PSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAIS 203
                :|...:.|.:........:::::..|. ..|.||:....|.|....||..||.::  :.:.
Mouse   156 CGELIAQLLQIPFLYSLRFSPGYQVEKNSGGFVLPPSYVPVILSGLGGQMTFTERVKNM--ICML 218

  Fly   204 WFN-WHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMH 267
            :|: |...:.:|....:  |...:.....|.|......:..:..::.|..|.|.:|||..|||:|
Mouse   219 YFDFWFQTFTEKEWDQF--YSETLGRPTTLIETMGKAEMWFIRSYWDLEFPHPTLPNVEYVGGLH 281

  Fly   268 IDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEE 332
            . :..|.|.:::|||:|.||.|||:.||||:.|  .||.::|...:..|...:||:|||:|:.:.
Mouse   282 C-KPAKPLPKEMEDFVQSSGVHGVVVFSLGSMV--SNMTEERANAISWALAQIPQKVLWRFDGKT 343

  Fly   333 LQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKK 397
            ...:..|..:.|||||.|||.|||.|.|:||||.....|:||:|.||:|:|.|.:|..|:.|:..
Mouse   344 PASLGPNTRIYKWLPQNDLLGHPKTKAFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDNIAHMVA 408

  Fly   398 HGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGA 462
            .|..::||...|:..:|...:.:::....::.........:.|||||||...::|..:|:|||||
Mouse   409 KGTAVALNIRTMSRSDLLNALEEVINNPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFVMRHKGA 473

  Fly   463 PHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAIL----LIIVFSVCKISKNISTRLVVKKQRK 523
            .|:|.....|:::.:|||||:|  .|::.:|..|:|    .:.|:           :..|||.:|
Mouse   474 KHLRPLAHNLTWYQYHSLDVIG--FLLVCVVATAVLPVKCCLFVY-----------QFFVKKAKK 525

  Fly   524 QK 525
            :|
Mouse   526 RK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	126/452 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	137/475 (29%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	140/488 (29%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	146/518 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840409
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690