DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	547	Identity:	157/547 - (28%)
Similarity:	262/547 - (47%)	Gaps:	93/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPS--EEPVKN---IYDIYVPEVLNSFDELLKQ 85
            ::|| .:||:.:....|..|...|||:|.:.|..|  .:|.|:   .::.:.....|...|::..
Mouse    28 VWPV-DYSHWMNIKIILDELKQKGHEVTVLRPSTSIFLDPKKSPGLKFETFPTSFSNDVMEIIFA 91

  Fly    86 MTTPKNTWE---------------FFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDLIIVDI 135
            ....:.|:|               .||..:::...:.||..:|   ::.:.:..:::||:|:.|
Mouse    92 KAVERWTYEVPRDTCLSYSPLLQNIFDEYSDYCLTLCKDTVSN---KQLMAKLQESKFDVILSD- 152

  Fly   136 WKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMV-------------------------GNPSPMS 175
                              .:.|||      |::                         |.|.|.|
Mouse   153 ------------------AIGPCG------ELIAELLQIPFLYSLRFSPGYYLEKYSGGLPLPPS 193

  Fly   176 YLQSPSSYLYNLDTFGGRVAHVVEVAISWFN-WHWRY-EQKHEALYKKYFPKIAETKPLSEISQD 238
            |:....|.|....||..||.::  :.:.:|: |...: |:|.:..|.:   .:.....|.|....
Mouse   194 YVPVILSGLSGQMTFKERVKNM--ICMLYFDFWFQTFREKKWDQFYSE---TLGRPTTLIETMGK 253

  Fly   239 IALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTK 303
            ..:.|:..::.|..|.|.:|||..|||:|. :..|.|.:::|||:|.||||||:.||||:.|  .
Mouse   254 AEMWLIRSYWDLEFPHPTLPNVYYVGGVHC-KPAKPLPKEMEDFVQSSGEHGVVVFSLGSMV--S 315

  Fly   304 NMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQS 368
            ||.:::...:..|...:||:|||:|:.:....:..|..:.|||||.|||.|||.|.||||||...
Mouse   316 NMTEEKANAIAWALAQIPQKVLWRFDGKTPATLGPNTRIYKWLPQNDLLGHPKTKAFITHGGANG 380

  Fly   369 TIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARI 433
            ..|:||:|.||:|:|.|.:|..|:.|:...|..::||...|:..:|...:.:::....::..|..
Mouse   381 LYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDLLNALEEVIDNPFYKENAMW 445

  Fly   434 AGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAIL 498
            ....:.|||||||:.||:|..:|:|||||.|:|.....|:::.:|||||:|.:|..:..::..|:
Mouse   446 LSTIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRPLAYNLTWYQYHSLDVIGFLLAFVTFIVALIV 510

  Fly   499 LIIVFSVCKISKNISTRLVVKKQRKQK 525
            ...:|..         |..|||::|.|
Mouse   511 KCFLFVY---------RFFVKKEKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	136/481 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	145/497 (29%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	149/514 (29%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	155/544 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840408
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690